Renoprotective effect and mechanism of polysaccharide from Polyporus umbellatus sclerotia on renal fibrosis
Renoprotective effect and mechanism of polysaccharide from Polyporus umbellatus sclerotia on renal fibrosis
复制标题
猪苓多糖对肾纤维化的保护作用及机制
DOI：
10.1016/j.carbpol.2019.02.026
复制
发表时间：
2019-05-15
影响因子：
11.2
通讯作者：
Xing, Changying
中科院分区：
文献类型：
--
作者：
Li, Hailun;Yan, Zhuan;Xing, Changying
猪苓菌核多糖（PPAS）是一种真菌多糖，具有显著的抗炎活性。鉴于炎症与肾纤维化的密切关系，以及其他真菌多糖在肾纤维化治疗中的重要作用，我们推测PPUS可能对肾纤维化具有治疗作用。然而，目前尚无关于经皮穿刺超声治疗该病的报道。本研究旨在探讨PPUS对肾纤维化的保护作用及其机制。结果表明，经皮肾穿刺超声能改善肾功能，减轻肾组织胶原沉积和纤维化程度。其作用机制与减轻炎症反应、抑制上皮-间质转化、重建基质金属蛋白酶及其组织抑制因子的平衡以及促纤维化因子和抗纤维化因子有关。结果提示，经皮肾穿刺超声可作为治疗肾间质纤维化的一种临床候选药物。
As a fungal polysaccharide, polysaccharide (PPUS) from Polyporus umbellatus sclerotia have showed remarkable anti-inflammatory activities. In view of the closely relationship between inflammation and renal fibrosis, and considering the significant role of other fungal polysaccharides on treatment of renal fibrosis, we speculated that PPUS may have therapeutic effects on renal fibrosis. However, there was not any reports about PPUS treatment this disease. The purpose of this paper is to investigate renoprotective effect and mechanism of PPUS on renal fibrosis. The results indicated that PPUS can improve renal function and ameliorate the degree of renal collagen deposition and further fibrosis. Its mechanism was found to be related with decreased inflammation, suppressive epithelial-mesenchymal transition, reconstructed the balance of matrix metalloproteinases and tissue inhibitor of metalloproteinases, and pro-fibrotic and anti-fibrotic factors. The data implied that PPUS can serve as a clinical candidate on treatment of renal interstitial fibrosis.