[Fatigue in patients with multiple sclerosis--pathogenesis, clinical picture, diagnosis and treatment].
[Fatigue in patients with multiple sclerosis--pathogenesis, clinical picture, diagnosis and treatment].
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DOI：
10.1055/s-0034-1399353
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发表时间：
2015-04
期刊：
影响因子：
--
通讯作者：
R. Patejdl;Penner Ik;T. Noack;U. K. Zettl
中科院分区：
文献类型：
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作者：
R. Patejdl;Penner Ik;T. Noack;U. K. Zettl
疲劳是多发性硬化症（MS）常见的限制性症状。本文从其发病机制出发，探讨多发性硬化症患者疲劳的鉴别诊断方法。在过去的几年里，功能成像技术的使用已经为这种高度可变的临床图像的机制提供了重要的信息。考虑到我们对免疫病理的相互依赖性和神经心理疾病的临床表现的理解的提高，免疫调节治疗和疲劳之间的关系正受到越来越多的关注。因此，本文不仅报道了疲劳对症治疗的药理学、生理和心理干预的最新数据，而且还特别强调了MS中数量迅速增加的免疫调节治疗之间相互作用的数据。
Fatigue is a frequent and restricting symptom of multiple sclerosis (MS). Starting from its pathogenetic mechanisms, the article develops an approach to the differential diagnosis of fatigue in MS patients. Over the past years, the use of functional imaging techniques has given important information on the mechanisms of this highly variable clinical picture. Considering our improved understanding of the interdependency of immune pathology and the clinical presentation of neuropsychological disorders, the relationship between immunomodulatory treatments and fatigue is receiving increased attention. Therefore, this article not only reports on the most recent data on pharmacological, physical and psychological interventions in the symptomatic treatment of fatigue, but also puts a special accent on data concerning the interactions between the rapidly growing number of immunomodulatory treatments in MS.