ROBIS: A new tool to assess risk of bias in systematic reviews was developed.
ROBIS: A new tool to assess risk of bias in systematic reviews was developed.
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DOI：
10.1016/j.jclinepi.2015.06.005
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发表时间：
2016-01
影响因子：
7.2
通讯作者：
ROBIS group
中科院分区：
文献类型：
--
作者：
Whiting P;Savović J;Higgins JP;Caldwell DM;Reeves BC;Shea B;Davies P;Kleijnen J;Churchill R;ROBIS group
开发ROBIS，一种评估系统评价（而不是初步研究）偏倚风险的新工具。我们采用了四阶段方法来开发ROBIS：定义范围，审查证据基础，举行面对面会议，并通过试点改进工具。ROBIS目前主要针对卫生保健机构内的四大类审查：干预措施、诊断、预后和病因。ROBIS的目标受众主要是指南开发者、系统评审概述（“评审的评审”）的作者，以及可能希望评估或避免评审中存在偏见风险的评审作者。该工具分三个阶段完成：(1)评估相关性（可选），(2)确定审查过程中的关注点，(3)判断偏见风险。第二阶段包括四个领域，通过这些领域，偏倚可能会被引入系统评价：研究资格标准；鉴定和选择研究；数据收集和研究评估；综合和发现。第3阶段评估评价结果解释的总体偏倚风险，以及是否考虑了在任何第2阶段领域中发现的局限性。包括信号问题，以帮助判断对审查过程的关注（阶段2）和审查中的总体偏倚风险（阶段3）；这些问题标志着与潜在偏倚相关的评价设计方面，旨在帮助评估者判断评价过程、结果和结论中的偏倚风险。ROBIS是第一个严格开发的工具，专门用于评估系统评价中的偏倚风险。
To develop ROBIS, a new tool for assessing the risk of bias in systematic reviews (rather than in primary studies). We used four-stage approach to develop ROBIS: define the scope, review the evidence base, hold a face-to-face meeting, and refine the tool through piloting. ROBIS is currently aimed at four broad categories of reviews mainly within health care settings: interventions, diagnosis, prognosis, and etiology. The target audience of ROBIS is primarily guideline developers, authors of overviews of systematic reviews (“reviews of reviews”), and review authors who might want to assess or avoid risk of bias in their reviews. The tool is completed in three phases: (1) assess relevance (optional), (2) identify concerns with the review process, and (3) judge risk of bias. Phase 2 covers four domains through which bias may be introduced into a systematic review: study eligibility criteria; identification and selection of studies; data collection and study appraisal; and synthesis and findings. Phase 3 assesses the overall risk of bias in the interpretation of review findings and whether this considered limitations identified in any of the phase 2 domains. Signaling questions are included to help judge concerns with the review process (phase 2) and the overall risk of bias in the review (phase 3); these questions flag aspects of review design related to the potential for bias and aim to help assessors judge risk of bias in the review process, results, and conclusions. ROBIS is the first rigorously developed tool designed specifically to assess the risk of bias in systematic reviews.