Overnight Consolidation Aids the Transfer of Statistical Knowledge from the Medial Temporal Lobe to the Striatum
Overnight Consolidation Aids the Transfer of Statistical Knowledge from the Medial Temporal Lobe to the Striatum
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DOI：
10.1093/cercor/bhs244
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发表时间：
2013-10-01
期刊：
影响因子：
3.7
通讯作者：
Lewis, Penelope A.
中科院分区：
文献类型：
--
作者：
Durrant, Simon J.;Cairney, Scott A.;Lewis, Penelope A.
睡眠对于抽象将概念上相关的刺激结合在一起的基本原则（或要点）很重要，但对这一过程的神经相关性知之甚少。在这里，我们调查这个问题，使用夜间睡眠监测和功能性磁共振成像（fMRI）。参与者被暴露在一个统计结构序列的听觉音调，然后立即测试识别短序列，符合学习的统计模式。随后，在30分钟或24小时的巩固后，他们进行了一个延迟的测试，其中大脑活动被功能磁共振成像监测。在行为上，24小时内的改善比30分钟内的改善更大，这是通过获得的慢波睡眠（SWS）量预测的。在功能上，我们观察到较弱的海马旁反应和较强的纹状体反应后，睡眠。与行为结果一样，这些功能反应的差异是通过获得的SWS量来预测的。此外，纹状体和海马旁之间的连接在睡眠后较弱，而壳核和颞平面之间的连接较强。两者合计，这些研究结果表明，抽象与逐渐从海马转移到纹状体记忆系统，这可能是介导的SWS。
Sleep is important for abstraction of the underlying principles (or gist) which bind together conceptually related stimuli, but little is known about the neural correlates of this process. Here, we investigate this issue using overnight sleep monitoring and functional magnetic resonance imaging (fMRI). Participants were exposed to a statistically structured sequence of auditory tones then tested immediately for recognition of short sequences which conformed to the learned statistical pattern. Subsequently, after consolidation over either 30 min or 24 h, they performed a delayed test session in which brain activity was monitored with fMRI. Behaviorally, there was greater improvement across 24 h than across 30 min, and this was predicted by the amount of slow wave sleep (SWS) obtained. Functionally, we observed weaker parahippocampal responses and stronger striatal responses after sleep. Like the behavioral result, these differences in functional response were predicted by the amount of SWS obtained. Furthermore, connectivity between striatum and parahippocampus was weaker after sleep, whereas connectivity between putamen and planum temporale was stronger. Taken together, these findings suggest that abstraction is associated with a gradual shift from the hippocampal to the striatal memory system and that this may be mediated by SWS.