Evidence from clinical and animal model studies of the long-term and transgenerational impact of stress on DNA methylation.
Evidence from clinical and animal model studies of the long-term and transgenerational impact of stress on DNA methylation.
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DOI：
10.1016/j.semcdb.2015.04.004
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发表时间：
2015-07
影响因子：
7.3
通讯作者：
Roth TL
中科院分区：
文献类型：
--
作者：
Blaze J;Roth TL
虽然众所周知，在发育和成年期的压力可以带来长期的神经生物学和行为后果，但研究人员最近才开始评估与这些后果相关的表观遗传修饰。在这篇综述中，我们强调了临床研究和动物模型的工作，这些动物模型提供了围产期或成年期压力经历对DNA甲基化和行为影响的证据。此外，我们探讨了更具争议性的跨代遗传概念，包括与母亲或父亲所经历的孕前压力相关的概念。最后，我们讨论了与跨代表观遗传学的想法和一般的表观遗传学领域的挑战。
While it is well-known that stress during development and adulthood can confer long-term neurobiological and behavioral consequences, investigators have only recently begun to assess epigenetic modifications associated with these consequences. In this review, we highlight clinical research and work with animal models that provide evidence of the impact of stressful experiences either during the perinatal period or adulthood on DNA methylation and behavior. Additionally, we explore the more controversial concept of transgenerational inheritance, including that associated with preconception stress experienced by the mother or father. Finally, we discuss challenges associated with the idea of transgenerational epigenetics and for the field of epigenetics in general.