Age-dependent increases in oxidative damage to DNA, lipids, and proteins in human skeletal muscle
Age-dependent increases in oxidative damage to DNA, lipids, and proteins in human skeletal muscle
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DOI：
10.1016/s0891-5849(98)00208-1
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发表时间：
1999-02-01
影响因子：
7.4
通讯作者：
Beal, MF
中科院分区：
文献类型：
--
作者：
Mecocci, P;Fanó, G;Beal, MF
氧化损伤在正常衰老中的作用得到了实验动物研究的支持，但在man. We研究了66例年龄在25至93岁的人肌肉活检标本中DNA，脂质和蛋白质的氧化损伤标记物的证据有限。8-羟基-2-脱氧鸟苷（OH（8）dG）（DNA氧化损伤的标志物）、丙二醛（MDA）（脂质过氧化的标志物）和蛋白质羰基（蛋白质氧化的标志物）在较小程度上呈年龄依赖性增加。OH（8）dG的增加与MDA的增加显著相关。这些结果为氧化损伤在人类衰老中的作用提供了证据，这可能有助于肌肉力量和耐力的年龄依赖性损失。(C)1998年爱思唯尔科学公司
A role for oxidative damage in normal aging is supported by studies in experimental animals, but there is limited evidence in man. We examined markers of oxidative damage to DNA, Lipids, and proteins in 66 muscle biopsy specimens from humans aged 25 to 93 years. There were age-dependent increases in 8-hydroxy-2-deoxyguanosine (OH(8)dG), a marker of oxidative damage to DNA, in malondialdehyde (MDA), a marker of lipid peroxidation, and to a lesser extent in protein carbonyl groups, a marker of protein oxidation. The increases in OH(8)dG were significantly correlated with increases in MDA. These results provide evidence for a role of oxidative damage in human aging which may contribute to age-dependent losses of muscle strength and stamina. (C) 1998 Elsevier Science Inc.