DIETARY PESTICIDES (99.99-PERCENT ALL NATURAL)
DIETARY PESTICIDES (99.99-PERCENT ALL NATURAL)
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DOI：
10.1073/pnas.87.19.7777
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发表时间：
1990-10-01
影响因子：
11.1
通讯作者：
GOLD, LS
中科院分区：
文献类型：
--
作者：
AMES, BN;PROFET, M;GOLD, LS
暴露于合成化学品的毒理学意义是在暴露于自然产生的化学品的背景下审查的。我们计算出，美国人饮食中99.99%(按重量计)的杀虫剂是植物为自卫而生产的化学物质。在大剂量动物癌症测试中，只有52种天然杀虫剂被测试，其中约一半(27种)是啮齿动物致癌物质；这27种被证明存在于许多常见食品中。我们得出结论，在动物癌症测试中，天然和合成化学物质呈阳性的可能性是一样的。我们还得出结论，在大多数人类暴露的低剂量下，合成农药残留的相对危害微乎其微。
The toxicological significance of exposures to synthetic chemicals is examined in the context of exposures to naturally occurring chemicals. We calculate that 99.99% (by weight) of the pesticides in the American diet are chemicals that plants produce to defend themselves. Only 52 natural pesticides have been tested in high-dose animal cancer tests, and about half (27) are rodent carcinogens; these 27 are shown to be present in many common foods. We conclude that natural and synthetic chemical are equally likely to be positive in animal cancer tests. We also conclude that at the low doses of most human exposures the comparative hazards of sythetic pesticide residues are insignificant.