Strengths, Weaknesses, and Opportunities of Diagnostic Breathomics in Pleural Mesothelioma-A Hypothesis
Strengths, Weaknesses, and Opportunities of Diagnostic Breathomics in Pleural Mesothelioma-A Hypothesis
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DOI：
10.1158/1055-9965.epi-13-0737
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发表时间：
2014-06-01
影响因子：
3.8
通讯作者：
van Meerbeeck, Jan P.
中科院分区：
文献类型：
--
作者：
Lamote, Kevin;Nackaerts, Kristiaan;van Meerbeeck, Jan P.
过去和现在的石棉使用将反映在未来几十年间皮瘤病例数量的增加，在晚期诊断和预后不佳。这强调了早期检测工具的必要性，这可以提高患者的存活率。近年来，呼吸分析作为一种非侵入性的快速诊断工具已经进入生物医学研究领域。高通量呼吸组学使用光谱、色谱和传感器技术，根据呼吸中的挥发性有机化合物（VOC）诊断石棉相关的肺部疾病。本文回顾了目前最先进的呼吸分析技术，并提供了当前使用挥发性有机化合物作为间皮瘤早期诊断或预后生物标志物的见解，以刺激该领域的进一步研究。(c) 2014年aacr。
Past and present asbestos use will reflect in increasing numbers of mesothelioma cases in the next decades, diagnosed at a late stage and with a dismal prognosis. This stresses the need for early detection tools, which could improve patients' survival. Recently, breath analysis as a noninvasive and fast diagnostic tool has found its way into biomedical research. High-throughput breathomics uses spectrometric, chromatographic, and sensor techniques to diagnose asbestos-related pulmonary diseases based upon volatile organic compounds (VOC) in breath. This article reviews the state-of-the-art available breath analyzing techniques and provides the insight in the current use of VOCs as early diagnostic or prognostic biomarkers of mesothelioma to stimulate further research in this field. (C) 2014 AACR.