Association of Health Aging and Body Composition (ABC) Heart Failure score with cardiac structural and functional abnormalities in young individuals.
Association of Health Aging and Body Composition (ABC) Heart Failure score with cardiac structural and functional abnormalities in young individuals.
复制标题
健康老龄化与身体成分协会 (ABC) 心力衰竭评分与年轻人心脏结构和功能异常的关系。
DOI：
10.1016/j.ahj.2010.02.001
复制
发表时间：
2010
影响因子：
4.8
通讯作者：
Drazner,MarkH
中科院分区：
文献类型：
--
作者：
Gupta,Sachin;Berry,JarettD;Ayers,ColbyR;Matulevicius,SusanA;Peshock,RonaldM;Patel,ParagC;Markham,DavidW;Drazner,MarkH
健康ABC心力衰竭评分最近被证明可以预测老年人发生心力衰竭的5年风险。我们测试了这种风险评分是否与年轻人群中心力衰竭的亚临床表型相关。方法我们将达拉斯心脏研究中年龄在30至65岁的参与者分层，这些参与者有心脏磁共振成像，并且没有自我报告的心力衰竭或心肌病史，分为4个先前定义的健康ABC心力衰竭风险组：低（<5%）、平均（5%-10%）、高（10%-20%）和非常高（5年内心力衰竭风险>20%）。我们比较了4组患者的左心室（LV）结构和功能参数以及B型利钠肽（BNP）和N末端proBNP水平。在研究队列（N = 2，540）中，低、中、高和极高风险组的受试者百分比分别为78%、15%、6%和1%。索引LV质量（80 ± 15 vs 90 ± 20 vs 95 ± 25 vs 116 ± 41 g/m2），同心度（1.6 ± 0.3 vs 1.8 ± 0.4 vs 2.0 ± 0.5 vs 2.2 ± 0.7 g/mL），中位BNP（2.8 vs 3.7 vs 4.9 vs 7.5 pg/mL）和N-末端proBNP（26 vs 30 vs 40 vs 58 pg/mL），在各风险组中，普遍的LV收缩功能障碍和LV肥大逐渐增加（P <0.001）与性别或LV质量指数化方法无关。结论健康ABC心力衰竭评分与30至65岁的一般人群中的亚临床心脏结构变化相关，这表明它可能是一个有效的工具，以确定年轻人的心脏衰竭的风险增加。
BACKGROUNDThe Health ABC Heart Failure score has recently been shown to predict 5-year risk of incident heart failure in the elderly. We tested whether this risk score is associated with subclinical phenotypes of heart failure in a younger population.METHODSWe stratified participants in the Dallas Heart Study aged 30 to 65 years who had a cardiac magnetic resonance imaging and no self-reported history of heart failure or cardiomyopathy into 4 previously defined Health ABC Heart Failure risk groups: low (<5%), average (5%-10%), high (10%-20%), and very high (>20% risk for heart failure within 5 years). We compared left ventricular (LV) structural and functional parameters and levels of B-type natriuretic peptide (BNP) and N-terminal proBNP among the 4 groups.RESULTSIn the study cohort (N = 2,540), the percentage of subjects in the low-, average-, high-, and very high risk groups was 78%, 15%, 6%, and 1%, respectively. Indexed LV mass (80 ± 15 vs 90 ± 20 vs 95 ± 25 vs 116 ± 41 g/m2), concentricity (1.6 ± 0.3 vs 1.8 ± 0.4 vs 2.0 ± 0.5 vs 2.2 ± 0.7 g/mL), median BNP (2.8 vs 3.7 vs 4.9 vs 7.5 pg/mL) and N-terminal proBNP (26 vs 30 vs 40 vs 58 pg/mL), and prevalent LV systolic dysfunction and LV hypertrophy progressively increased across risk groups (P < .001 for all) independent of gender or method of indexing LV mass.CONCLUSIONSThe Health ABC Heart Failure score was associated with subclinical cardiac structural changes in the general population 30 to 65 years of age, suggesting that it may be a valid tool for identification of young individuals at increased risk for heart failure.