Preventive effect of Juzen-taiho-to on endometrial carcinogenesis in mice is based on Shimotsu-to constituent
Preventive effect of Juzen-taiho-to on endometrial carcinogenesis in mice is based on Shimotsu-to constituent
复制标题
DOI：
10.1248/bpb.27.156
复制
发表时间：
2004-02-01
影响因子：
2
通讯作者：
Tamaya, T
中科院分区：
文献类型：
--
作者：
Tagami, K;Niwa, K;Tamaya, T
十善大宝汤是一种汉方配方，最初是由下津汤和四君汤配方以及另外两种原料混合而成。据报道，Juzen-taiho-to对小鼠子宫内膜癌的发生具有预防作用。Shimotsu-to对雌激素诱导的卵巢切除小鼠子宫中c-fos、白细胞介素（IL）-1 α和肿瘤坏死因子（TNF）-α的表达具有抑制作用。在本研究中，设计了短期和长期实验，以确定Juzen-taiho-to和Shimotsu-to对小鼠子宫雌激素相关子宫内膜癌发生的影响，并与环氧合酶（考克斯）的表达相关-1和-2。在短期实验中，暴露于Juzen-taiho-to或Shimotsu-to显著降低雌二醇-17 β（E-2）刺激的考克斯-2 mRNA表达（p
Juzen-taiho-to, a Kampo formula, originally consists of a mixture of Shimotsu-to and Shikunshi-to formulas together with two other crude ingredients. Juzen-taiho-to is reported to have a preventive effect on endometrial carcinogenesis in mice. Shimotsu-to exerts an inhibitory effect on estrogen-induced expression of c-fos, interleukin (IL)-1alpha and tumor necrosis factor (TNF)-alpha in uteri of ovarectornized mice. In the present study, short- and long-term experiments were designed to determine the effects of Juzen-taiho-to and Shimotsu-to on the estrogen-related endometrial carcinogenesis in mouse uteri, associated with the expression of cyclooxygenase (COX)-1 and -2. In the short-term experiment, exposure to Juzen-taiho-to or Shimotsu-to significantly reduced estradiol-17beta (E-2)-stimulated expressions of COX-2 mRNA (p