Perspectives of SLIT/ROBO signaling in placental angiogenesis.
Perspectives of SLIT/ROBO signaling in placental angiogenesis.
复制标题
胎盘血管生成中缝隙/机器人信号传导的观点。
DOI：
10.14670/hh-25.1181
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发表时间：
2010-09
影响因子：
2
通讯作者：
Chen DB
中科院分区：
文献类型：
--
作者：
Liao WX;Wing DA;Geng JG;Chen DB
一种新的进化保守的神经元引导因子家族，包括配体（即，Slit、netrin、epherin和semaphorin）及其相应的受体（即，Robo、DCC/Unc5、Eph和丛蛋白/神经纤毛蛋白）在轴突寻路和分支以及神经元细胞迁移中起关键作用。神经和血管发育的共同性的存在导致了最近一些令人兴奋的发现，这些发现将这些系统的功能扩展到血管形成（血管发生）和发育（血管生成）。已经发现这些配体和受体中的一些在生理和病理条件下在脉管系统和周围组织中表达。据推测，它们调节血管的形成和完整性。特别是，已经表明，Slit/Robo对在肿瘤发生过程中的血管生成和胚胎发生过程中的血管形成中起着新的作用。在此，我们简要总结了这个家庭的神经元导向分子的特点，并讨论了神经外的表达和功能的Slit/Robo对血管生成的生理和病理设置。我们报告Robo1蛋白在毛细血管内皮细胞中的表达，以及Slit2和Robo1蛋白在健康足月人胎盘绒毛合胞体滋养层中的共表达。这些细胞表达模式暗示Slit/Robo信号在血管生成和滋养层功能中起自分泌和/或旁分泌作用。我们还推测该系统在病理生理学胎盘血管生成中的可能作用。
A novel family of evolutionally conserved neuronal guidance cues, including ligands (i.e., Slit, netrin, epherin, and semaphorin) and their corresponding receptors (i.e., Robo, DCC/Unc5, Eph and plexin/neuropilin), has been identified to play a crucial role in axon pathfinding and branching as well as neuronal cell migration. The presence of commonalities in both neural and vascular developments has led to some exciting discoveries recently, which have extended the functions of these systems to vascular formation (vasculogenesis) and development (angiogenesis). Some of these ligands and receptors have been found to be expressed in the vasculature and surrounding tissues in physiological and pathological conditions. It is postulated that they regulate the formation and integrity of blood vessels. In particular, it has been shown that the Slit/Robo pair plays a novel role in angiogenesis during tumorigenesis and vascular formation during embryogenesis. Herein we summarize briefly the characteristics of this family of neuronal guidance molecules and discuss the extra-neural expression and function of the Slit/Robo pair in angiogenesis in physiological and pathological settings. We report expression of Robo1 protein in capillary endothelium and co-expression of Slit2 and Robo1 proteins in syncytiotrophoblast in healthy term human placental villi. These cellular expression patterns implicate that the Slit/Robo signaling plays an autocrine and/or paracrine role in angiogenesis and trophoblast functions. We also speculate a possible role of this system in pathophysiological placental angiogenesis.