Necrotizing enterocolitis in premature infants and newborns.
Necrotizing enterocolitis in premature infants and newborns.
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DOI：
10.3233/npm-16915130
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发表时间：
2016-09-16
影响因子：
--
通讯作者：
Seeliger, S
中科院分区：
文献类型：
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作者：
Mϋller, M J;Paul, T;Seeliger, S
坏死性小肠结肠炎（NEC）是早产儿和新生儿最常见的获得性胃肠道疾病（GIT）。它被定义为肠壁的溃疡性炎症。初期NEC的临床体征通常非常离散，范围从局部肠道症状到全身性脓毒症体征。NEC根据其严重程度根据修改的Bell分类法被分类为疾病状态。NEC的治疗范围取决于其严重程度，从保守的治疗方法到切除受影响肠部分的手术。极小早产儿的死亡率相当高，高达受影响儿童的42%。应尽早考虑采取措施，如母乳喂养或从母乳库中使用经巴氏灭菌的人类供体母乳进行营养，给予益生菌，避免使用组胺II型受体拮抗剂和限制性抗生素治疗，以预防NEC。
Necrotizing enterocolitis (NEC) is the most common acquired disease of the gastrointestinal tract (GIT) in premature infants and newborns. It is defined as an ulcerative inflammation of the intestinal wall. The clinical signs of incipient NEC are often very discrete, and range from localized intestinal symptoms to generalized signs of sepsis. NEC is classified depending on its severity into disease states according to the modified Bell's Classification. Treatment of NEC ranges, depending on its severity, from a conservative therapeutic approach to surgery with resection of the affected parts of the intestine. Mortality is considerably high in extremely small preterm infants reaching up to 42% of the affected children. Measures such as breastfeeding or alternatively nutrition with pasteurized human donor milk from a milk bank, administration of probiotics, avoidance of histamine type II receptor antagonists, and restrictive antibiotic treatment should be considered early on for prevention of NEC.