Pathological changes of renal tubular dysplasia in Japanese Black cattle
Pathological changes of renal tubular dysplasia in Japanese Black cattle
复制标题
日本黑牛肾小管发育不良的病理变化
DOI：
--
复制
发表时间：
2002
期刊：
影响因子：
--
通讯作者：
T. Masegi
中科院分区：
文献类型：
--
作者：
Y. Sasaki;H. Kitagawa;K. Kitoh;Y. Okura;K. Suzuki;M. Mizukoshi;Y. Ohba;T. Masegi
Pathological studies were conducted on 91 Japanese Black cattle with a hereditary disease which induced growth retardation, long hooves and renal failure. In calves one to two months old, no gross abnormalities were observed in the kidneys, but microscopical examinations revealed immature epithelia which were arranged irregularly and not attached to the basement membranes in some proximal tubules. In animals three to 36 months old, the kidneys had shrunk perceptibly and had grey-white radial streaks; microscopically they showed severe interstitial fibrosis with round-cell infiltration in the outer zone of the medulla and cortex, and reductions in the numbers of glomeruli and tubules. In the fibrotic areas there were immature epithelia with an irregular arrangement, and the basement membrane of the tubules was thickened. It was concluded that renal tubular dysplasia was the primary lesion of the disease, and that interstitial fibrosis and reductions in the numbers of nephrons were secondary lesions.
影响因子：
56.9
作者：
Simon, DB;Lu, Y;Lifton, RP
通讯作者：
Lifton, RP