Parallel Evolution of Common Allelic Variants Confers Flowering Diversity in Capsella rubella
Parallel Evolution of Common Allelic Variants Confers Flowering Diversity in Capsella rubella
复制标题
常见等位基因变异的平行进化赋予荠菜开花多样性
DOI：
10.1105/tpc.18.00124
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发表时间：
2018
期刊：
影响因子：
11.6
通讯作者：
Guo Ya Long
中科院分区：
文献类型：
--
作者：
Yang Li;Wang Hui Na;Hou Xing Hui;Zou Yu Pan;Han Ting Shen;Niu Xiao Min;Zhang Jie;Zhao Zhong;Todesco Marco;Balasubramanian Sureshkumar;Guo Ya Long
开花时间是一种适应生活史的轨迹。风帽是拟南芥和一个年轻物种的近亲，它在开花时间上表现出广泛的变异，但由于极端的瓶颈事件，遗传变异很小，这为理解在有限的初始基因库中表型多样性是如何发生的提供了一个很好的机会。在这里，我们证明了在FLC基因座上常见的等位基因变异和平行进化导致了开花时间的变异。Rubella.我们发现在OFC的5‘非翻译区有两个重叠的缺失。风疹FLC与染色质构象和组蛋白修饰的局部变化有关，降低其表达水平，促进开花。我们进一步证明，这两个普遍存在的变体独立地起源于Natural C。物种形成后，风铃种群数量增加，并传播到中等频率，这表明这种平行调控变化在适应性进化中发挥了作用。我们的结果提供了一个例子，说明在相同的5‘UTR区域中的平行突变如何塑造植物的表型进化。
Flowering time is an adaptive life history trait.Capsella rubella, a close relative ofArabidopsis thalianaand a young species, displays extensive variation for flowering time but low standing genetic variation due to an extreme bottleneck event, providing an excellent opportunity to understand how phenotypic diversity can occur with a limited initial gene pool. Here, we demonstrate that common allelic variation and parallel evolution at theFLClocus confer variation in flowering time inC. rubella.We show that two overlapping deletions in the 5′ untranslated region (UTR) ofC. rubella FLC, which are associated with local changes in chromatin conformation and histone modifications, reduce its expression levels and promote flowering. We further show that these two pervasive variants originated independently in naturalC. rubellapopulations after speciation and spread to an intermediate frequency, suggesting a role of this parallelcis-regulatory change in adaptive evolution. Our results provide an example of how parallel mutations in the same 5′ UTR region can shape phenotypic evolution in plants.