DEPRESSED MOOD AND OTHER VARIABLES RELATED TO BONE-MARROW TRANSPLANTATION SURVIVAL IN ACUTE-LEUKEMIA
DEPRESSED MOOD AND OTHER VARIABLES RELATED TO BONE-MARROW TRANSPLANTATION SURVIVAL IN ACUTE-LEUKEMIA
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DOI：
10.1016/s0033-3182(91)72045-8
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发表时间：
1991-09-01
期刊：
影响因子：
3.4
通讯作者：
MCGLAVE, PB
中科院分区：
文献类型：
--
作者：
COLON, EA;CALLIES, AL;MCGLAVE, PB
对 100 名接受同种异体骨髓移植治疗急性白血病的成年患者进行的常规精神评估进行了回顾，以研究精神和心理社会因素与手术后生存时间的可能关系。 研究发现三个变量独立影响结果：疾病状态（首次缓解与其他状态）、抑郁情绪的存在以及感知社会支持的程度。 在首次缓解期间接受移植的患者的生存率显着提高；情绪抑郁的患者，无论具体的精神病学诊断如何，结果都较差；具有高水平感知社会支持的患者生存率有所提高。 讨论了这些变量影响结果的可能机制。
Routine psychiatric evaluations of 100 adult patients undergoing allogeneic bone marrow transplantation for acute leukemia were reviewed to examine the possible relationship of psychiatric and psychosocial factors to duration of survival following the procedure. Three variables were found to independently affect outcome: illness status (first remission vs. other status), presence of depressed mood, and the extent of perceived social support. Patients transplanted while in their first remission had significantly improved survival; patients with depressed mood, regardless of specific psychiatric diagnosis, had poorer outcomes; and patients with a high level of perceived social support had improved survival. The possible mechanisms by which these variables affect outcome are discussed.