A Case for Translation From the Clinic to the Laboratory.
A Case for Translation From the Clinic to the Laboratory.
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DOI：
10.1177/17456916211039852
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发表时间：
2022-07
影响因子：
12.6
通讯作者：
Phelps, Elizabeth A.
中科院分区：
文献类型：
--
作者：
Kredlow, M. Alexandra;de Voogd, Lycia D.;Phelps, Elizabeth A.
关键词：
几十年来，实验室程序一直被用作临床过程的类似物，目的是提高我们对情绪障碍心理治疗的理解，并确定使治疗更有效的策略。这项研究通常侧重于从实验室到临床的转化。尽管这种方法取得了显着的成功，但它并不是无缝的。最近有许多在实验室有效的策略在临床应用时未能改善结果的例子。实验和临床研究之间存在这种差距的一个可能原因是未能专注于从临床到实验室的转化。在这里，我们讨论从诊所到实验室的潜在好处，并提供如何实施的示例。我们首先考虑两个成熟的实验室类似物（消退和认知重新评估），确定这些类似物中缺失的相关临床程序（暴露和认知重建）的关键方面，并提出变化以更好地捕捉临床过程。其次，我们讨论最近被带入实验室的两种临床程序（眼动脱敏和再处理以及图像重写）。最后，我们强调了这一拟议的转化研究重点转变的潜在影响。
Laboratory procedures have been used for decades as analogues for clinical processes with the goal of improving our understanding of psychological treatments for emotional disorders and identifying strategies to make treatments more effective. This research has often focused on translation from the laboratory to the clinic. Although this approach has notable successes, it has not been seamless. There are many recent examples of strategies that work in the laboratory that fail to lead to improved outcomes when applied clinically. One possible reason for this gap between experimental and clinical research is failure to focus on translation from the clinic to the laboratory. Here, we discuss potential benefits of translation from the clinic to the laboratory and provide examples of how this might be implemented. We first consider two well-established laboratory analogues (extinction and cognitive reappraisal), identify critical aspects of the related clinical procedures (exposure and cognitive restructuring) that are missing from these analogues, and propose variations to better capture the clinical process. Second, we discuss two clinical procedures that have more recently been brought into the laboratory (eye movement desensitization and reprocessing and imagery rescripting). We conclude by highlighting potential implications of this proposed shift in focus for translational research.
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影响因子：
3.1
作者：
Andrade, J;Kavanagh, D;Baddeley, A
通讯作者：
Baddeley, A
影响因子：
3.7
作者：
Abramowitz, Jonathan S.
通讯作者：
Abramowitz, Jonathan S.
影响因子：
5.3
作者：
Beauregard, M;Lévesque, J;Bourgouin, P
通讯作者：
Bourgouin, P
影响因子：
3.7
作者：
Buhle, Jason T.;Silvers, Jennifer A.;Ochsner, Kevin N.
通讯作者：
Ochsner, Kevin N.
DOI：
10.3758/bf03197954
发表时间：
1992-11-01
期刊：
ANIMAL LEARNING & BEHAVIOR
影响因子：
--
作者：
BOUTON, ME;PECK, CA
通讯作者：
PECK, CA