BAHD-like malonyltransferase genes from Digitalis lanata and Arabidopsis thaliana and their putative role in cardenolide biosynthesis
BAHD-like malonyltransferase genes from Digitalis lanata and Arabidopsis thaliana and their putative role in cardenolide biosynthesis
复制标题
来自毛地黄和拟南芥的 BAHD 样丙二酰转移酶基因及其在强心内酯生物合成中的假定作用
DOI：
10.1055/s-0039-3399788
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发表时间：
2019
期刊：
影响因子：
2.7
通讯作者：
W Kreis
中科院分区：
文献类型：
--
作者：
M Tropper;S Höhn;J Munkert;W Kreis
用于治疗充血性心力衰竭的Cardenolide仍然是从植物中提取出来的。以酵母为基础的代谢工程方法可以获得一种更有效的方法来生产Cardenolide[1]。丙二酰辅酶A：21-羟基孕烷21-O-丙二酰基转移酶(21MaT)催化孕烷前体生成孕烷-21-O-丙二酸半酯。尽管已经鉴定出紫花蛇舌草的21MaT基因[2]，但至今还没有鉴定出21MaT基因。
Cardenolides, which are used for the treatment of congestive heart failure, are still produced by extraction from plants. A more efficient way to produce cardenolides could be achieved by a yeast-based metabolic engineering approach [1]. However, several steps in cardenolide biosynthesis still need to be elucidated.Malonyl-coenzymeA: 21-hydroxypregnane 21-O-Malonyltransferase (21MaT) catalyzes the formation of pregnane-21-O-malonyl hemiesters from pregnane precursors. Even though a 21MaT from D. purpurea has already been characterized [2], no 21MaT gene could be identified as yet.