Reactivation of herpesvirus infections after vaccinations?
Reactivation of herpesvirus infections after vaccinations?
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DOI：
10.1016/s0140-6736(99)00623-6
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发表时间：
1999-03-06
期刊：
影响因子：
168.9
通讯作者：
Kuhn, M
中科院分区：
文献类型：
--
作者：
Walter, R;Hartmann, K;Kuhn, M
水痘带状疱疹病毒和单纯疱疹病毒在初次感染后持续存在于感觉神经或神经元周围的卫星细胞中，从而引起潜伏感染。再激活与年龄增长、艾滋病毒感染和水痘带状疱疹病毒感染中的癌症有关，并且与单纯疱疹病毒感染中的身体或情绪压力、发烧、暴露于紫外线、组织损伤和免疫抑制有关。 1, 2 向瑞士药物监测中心 SANZ 报告的三例病例提供了接种其他（非疱疹）病毒疫苗后疱疹病毒感染重新激活的证据。患者 1 是一名 53 岁白人妇女，没有定期服药，于 1998 年 4 月接受了第一剂甲醛灭活甲型肝炎疫苗（瑞士伯尔纳）。14 天后，左侧 T-10 皮区出现带状疱疹，已解决，无后遗症。 1998 年 9 月，接种了第二剂甲醛灭活甲型肝炎疫苗（SmithKline Beecham，Thörishaus，瑞士）。接种后第 8 天出现唇疱疹，左侧 L1 皮区出现带状疱疹，伴有根性疼痛、感觉过敏（第 12 天）和水疱疹（第 16 天）。该患者接受了伐昔洛韦治疗，恢复时间较长。艾滋病毒检测呈阴性。
Varicella zoster and herpes simplex viruses cause latent infections by persisting in sensory nerves or satellite cells around neurons after primary infection. Reactivation has been associated with increasing age, HIV infection, and cancer in varicella zoster virus infection, and with physical or emotional stress, fever, exposure to ultraviolet light, tissue damage, and immunosuppression in herpes simplex virus infection. 1, 2 Three cases reported to the Swiss Drug Monitoring Centre SANZ provide evidence for reactivation of herpesvirus infections after vaccinations against other (non-herpes) viruses.Patient 1, a 53-year-old white woman on no regular medication, received her first dose of a formaldehydeinactivated hepatitis A vaccine (Berna, Bern, Switzerland) in April, 1998. 14 days later, herpes zoster developed in the left T-10 dermatome, which resolved without sequelae. A second dose of a formaldehyde-inactivated hepatitis A vaccine (SmithKline Beecham, Thörishaus, Switzerland) was given in September, 1998. Herpes labialis developed on day 8 after vaccination, and herpes zoster with radicular pain, hyperaesthesia (on day 12), and vesicular eruptions (on day 16) developed in the left L1 dermatome. The patient was treated with valaciclovir with prolonged recovery. An HIV test was negative.