Green tea extract prolongs allograft survival as an adjunctive therapy along with low dose cyclosporine A.
Green tea extract prolongs allograft survival as an adjunctive therapy along with low dose cyclosporine A.
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绿茶提取物与低剂量环孢菌素 A 一起作为辅助疗法可延长同种异体移植物的存活率。
DOI：
10.1016/j.jss.2008.05.005
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发表时间：
2009
期刊：
影响因子：
--
通讯作者：
Kittur,DilipS
中科院分区：
文献类型：
--
作者：
Tripathi,Sudipta;Bruch,David;Gatto,LouisA;Kittur,DilipS
目前的免疫抑制药物成功地延长了同种异体移植物的存活率，但未能实现移植耐受或预防慢性排斥反应。因此，正在进行研究开发新的组合疗法，这些疗法在延长同种异体移植物存活以及诱导对移植器官的耐受性方面更有效。本研究旨在研究绿茶提取物（GTE）与低剂量环孢素 A（CyA）联合使用在延长小鼠同种异体移植物存活方面的功效。许多研究报道了 GTE 及其各种儿茶素成分的抗炎和免疫调节特性。 GTE 还可以减轻 CyA 诱导的肾毒性。因此，我们假设单独使用 GTE 或与 CyA 联合使用会延长移植物的存活时间。我们的研究表明，GTE 与低剂量 CyA 联合使用可显着延长移植物存活时间并增加免疫抑制细胞因子 IL-10 的产生。 GTE 还能降低 CyA 诱导的高 TGF-β 产生，这与 CyA 诱导的肾毒性有关。我们还观察到 GTE 在体外抑制 T 细胞的非特异性和抗原特异性增殖。这些结果表明 GTE 与 CyA 联合作为辅助治疗可延长同种异体移植物存活并减少 CyA 诱导的肾毒性。
The current immunosuppressive drugs are successful in prolonging allograft survival but fail to achieve transplantation tolerance or prevent chronic rejection. Consequently, there is ongoing research to develop novel combinatorial therapies that are more efficacious in prolonging allograft survival as well as induce tolerance toward the transplanted organ. The present study aims to study the efficacy of green tea extract (GTE) in combination with low dose cyclosporine A (CyA) in prolonging allograft survival in mice. Numerous studies have reported the anti-inflammatory and immunomodulatory properties of GTE and its various catechin components. GTE is also known to attenuate CyA induced nephrotoxicity. Therefore, we hypothesized that GTE alone or in combination with CyA will prolong graft survival. Our study demonstrates that GTE in combination with low dose CyA significantly prolongs graft survival as well as increase the production of immunosuppressive cytokine, IL-10. GTE also decreases CyA induced high TGF-β production, which is incriminated in CyA induced nephrotoxicity. We also observed that GTE inhibits both nonspecific and antigen-specific proliferation of T cells in vitro. These results indicate the potential of GTE as an adjunctive therapy in combination with CyA to prolong allograft survival and to reduce CyA induced nephrotoxicity.
影响因子：
14.2
作者：
Williamson, Mike P.;McCormick, Theron G.;Shearer, William T.
通讯作者：
Shearer, William T.
影响因子：
8.2
作者：
S. Shi;Shu-sen Zheng;C. Jia;You-fa Zhu;Hai Xie
通讯作者：
S. Shi;Shu-sen Zheng;C. Jia;You-fa Zhu;Hai Xie