Erratum to: PI3K/mTOR inhibition can impair tumor invasion and metastasis in vivo despite a lack of antiproliferative action in vitro: implications for targeted therapy.
Erratum to: PI3K/mTOR inhibition can impair tumor invasion and metastasis in vivo despite a lack of antiproliferative action in vitro: implications for targeted therapy.
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勘误表：尽管体外缺乏抗增殖作用，但 PI3K/mTOR 抑制可损害体内肿瘤侵袭和转移：对靶向治疗的影响。
DOI：
10.1007/s10549-016-3752-9
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发表时间：
2016
影响因子：
3.8
通讯作者：
Slingerland,JoyceM
中科院分区：
文献类型：
--
作者：
Wander,SethA;Zhao,Dekuang;Besser,AlexandraH;Hong,Feng;Wei,Jianqin;Ince,TanA;Milikowski,Clara;Bishopric,NanetteH;Minn,AndyJ;Creighton,ChadJ;Slingerland,JoyceM
Expression of a phosphomimetic, cell-cycle inert p27 mutant conveys resistance to PF1502. a Western analysis shows GFP-p27CK-T157DT198D (p27CK-DD) expression in 231 and 1833 (control represents empty-vector transfection). b Migration in 231+/− PF1502 with or without p27CK-T157DT198D, mean+/− SEM (T-test of 231p27CK-DD (top) and 231 (bottom) with or without drug* p= 0.01,‡ p= 0.11; 231CK-DD vs. 231 control p< 0.0001). c–d, Matrigel invasion of 231 (c) and 1833 cells (d) transduced with p27CK-DD, with and without 48 h PF1502 250 nM and graphed+/− SEM.(T-tests as indicated:* p= 0.003,‡ p= 0.068 (left);* p= 0.0002,‡ p= 0.064 (right))(c, d)
