New class azaphilone produced by a marine fish-derived Chaetomium globosum. The stereochemistry and biological activities
New class azaphilone produced by a marine fish-derived Chaetomium globosum. The stereochemistry and biological activities
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DOI：
10.1016/j.bmc.2011.05.008
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发表时间：
2011-07-01
影响因子：
3.5
通讯作者：
Tanaka, Reiko
中科院分区：
文献类型：
--
作者：
Yamada, Takeshi;Muroga, Yasuhide;Tanaka, Reiko
从海鱼毛囊毛囊菌（chetomugilins P-R）中分离到4个新的代谢物，分别为毛囊毛囊素（chaetomugilins P-R）和毛囊毛囊素（11-epi-chaetomugilin I），并通过光谱分析（包括1D和2D NMR技术以及各种化学转化）对其绝对立体结构进行了鉴定。特别是，chaetomugilin P的骨架不同于迄今为止从该真菌菌株中分离到的其他氮蚜酮。此外，这些化合物还能显著抑制培养的P388、HL-60、L1210和KB细胞株的生长。(C) 2011 Elsevier Ltd.版权所有。
Four new metabolites, chaetomugilins P-R and 11-epi-chaetomugilin I, were isolated from a strain of Chaetomium globosum originally obtained from the marine fish Mugil cephalus, and their absolute stereo-structures were elucidated on the basis of spectroscopic analyses, including 1D and 2D NMR techniques and various chemical transformations. Particularly, the skeleton of chaetomugilin P is different from that of other azaphilones isolated from this fungal strain to date. In addition, these compounds significantly inhibited the growth of cultured P388, HL-60, L1210 and KB cell lines. (C) 2011 Elsevier Ltd. All rights reserved.