Early-life dietary and epigenetic influences on childhood musculoskeletal health: Update on the UK component of the ALPHABET project
Early-life dietary and epigenetic influences on childhood musculoskeletal health: Update on the UK component of the ALPHABET project
复制标题
DOI：
10.1111/nbu.12322
复制
发表时间：
2018-06-01
影响因子：
3.3
通讯作者：
Harvey, N. C.
中科院分区：
文献类型：
--
作者：
Curtis, E. M.;Suderman, M.;Harvey, N. C.
字母表项目由欧洲研究区域健康饮食健康生活生物标记物呼吁资助，旨在扩大关于饮食、表观遗传学和后代健康之间相互作用的知识库，表征可能为未来健康战略提供信息的生物标记物。这篇综述集中在英国生物技术和生物科学研究理事会(BBSRC)资助的部分，其目的是(1)产生和整理早期生命表观遗传学数据，(2)调查早期饮食和表观遗传学标记作为以后骨骼健康的预测因素。该项目建立在大量证据的基础上，这些证据表明环境因素，如母亲的饮食和身体成分，对后代的长期健康和发育有影响，而且这些关系可能至少部分通过表观遗传信号来调节。在动物模型中的实验研究表明，在怀孕期间操纵母亲的饮食会导致后代表观遗传标记和表型的改变。人体研究令人信服地证明了早期环境与后来的健康和疾病之间的关系，这些结果涉及肌肉骨骼、呼吸、神经发育和心脏代谢健康。现在的当务之急是找到将这种观察转化为改善终身健康的方法。一种关键的方法是确定不良健康后果的早期生物标记物，然后在旨在确定优化整个生命过程健康的战略的试验中测试这些标记物和后续干预措施。字母表项目将为肌肉骨骼成果的这一进程提供信息，整个项目不仅应有助于阐明新的机制，而且还应有助于阐明可能的战略，以减轻子孙后代肌肉骨骼、呼吸系统、神经发育和心脏代谢性疾病的负担。
The ALPHABET project, funded through the European Research Area Healthy Diet for a Healthy Life Biomarkers call, aims to expand the knowledge base regarding interactions between diet, epigenetics and offspring health, characterising biomarkers that may inform future health strategies. This review focuses on the UK Biotechnology and Biological Sciences Research Council (BBSRC)-funded component in which the aim was to (1) generate and collate early-life epigenetic data and (2) investigate early diet and epigenetic marks as predictors of later bone health. The project builds on a wealth of evidence implicating environmental factors, such as maternal diet and body composition, as influences on the long-term health and development of the offspring, and that these relationships might be mediated at least in part through epigenetic signals. Experimental studies in animal models have demonstrated that manipulation of maternal diet during pregnancy leads to altered offspring epigenetic marking and phenotype. Human studies convincingly demonstrate associations between early environment and later health and disease for outcomes across musculoskeletal, respiratory, neurodevelopmental and cardiometabolic health. The priority now is to find ways in which such observations can be translated into improved lifelong health. A key approach is to identify early biomarkers of adverse health outcomes and then to test these, and subsequent interventions, in trials aimed at identifying strategies to optimise health throughout the life course. The ALPHABET project will inform this process for musculoskeletal outcomes, and the project as a whole should help elucidate not only novel mechanisms, but also potential strategies to reduce the burden of musculoskeletal, respiratory, neurodevelopmental and cardiometabolic disease in future generations.