Microfluidic Systems in CNS Studies
Microfluidic Systems in CNS Studies
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DOI：
10.1007/978-3-030-36588-2_6
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发表时间：
2020-01-01
期刊：
影响因子：
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通讯作者：
Janowski, Miroslaw
中科院分区：
文献类型：
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作者：
Andrzejewska, Anna;Janowski, Miroslaw
目前的技术进步促进了将微型装置引入生物技术研究，包括中枢神经系统的研究。具有多种通道系统和多个隔室的各种微腔室使用户能够创建紧密模拟神经组织结构的模型，现在通常被称为芯片上的大脑技术。因此，在微流体装置中进行了显示物质梯度、细胞相互作用、空间条件、神经炎症、干细胞迁移、药物递送、控制疾病如阿尔茨海默病、帕金森病、多发性硬化症或神经损伤的进展的机制的影响的实验。此外，生物传感器的集成和用于微流体研究的专用软件的开发可以使得能够在很好地模拟中枢神经系统结构的模型中进行高通量和高质量的自动化实验，研究再生和退化过程。
Current technological progress facilitates the introduction of micro-devices into biotechnology research including studies on central nervous system. Wide range of micro-chambers with diversity of channel systems and multiple compartments enable users to create models which closely mimic nervous tissue structure which nowadays is often called as brain-on-a-chip technology. Heretofore experiments showing the influence of substance gradients, cell interactions, spatial conditions, neuroinflammation, stem cells migration, drug delivery, mechanisms controlling progression of diseases like Alzheimer, Parkinson, multiple sclerosis or nerve injury were performed in microfluidic devices. Moreover, the integration of bio-sensors and development of dedicated software for microfluidic studies can enable performing high throughput and good quality automated experiments investigating regeneration and degeneration processes in models well emulating central nervous system structures.