Persistence of human parvovirus B19 in human tissues
Persistence of human parvovirus B19 in human tissues
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DOI：
10.1016/s0369-8114(02)00307-3
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发表时间：
2002-06-01
影响因子：
--
通讯作者：
Hedman, K
中科院分区：
文献类型：
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作者：
Söderlund-Venermo, M;Hokynar, K;Hedman, K
人类细小病毒 B19 感染会引起各种临床症状，如皮疹、关节病、贫血和胎儿死亡，但也可能无症状。关节病和贫血可能会持续数年，类似于自身免疫综合征。 B19 仅在骨髓或胎儿肝脏的红细胞前体中复制，导致高滴度的短寿命病毒血症，但在其他几种类型的细胞中也可检测到病毒 DNA。最近，通过非常灵敏的扩增测试，不仅在有症状的人的某些组织中，而且在 B19 感染后数年或数十年的健康个体的某些组织中也发现了 B19 DNA。因此，仅在有症状患者的这些组织（例如慢性关节炎的关节或皮肌炎的皮肤）中存在 1319 DNA 并不能证明当前的疾病是由 B19 引起的。诊断必须通过其他创新手段来验证。病毒 DNA 如何以及为何在健康个体的组织中持续存在，目前正在研究中。 (C) 2002 年科学与医学版 Elsevier SAS。
Human parvovirus B19 infection causes various clinical symptoms, such as rash, arthropathy, anemias and fetal death, but it can also remain asymptomatic. The arthropathies and anemias can become chronic for several years, not infrequently resembling autoimmune syndromes. B19 replicates only in red blood cell precursors of bone marrow or fetal liver, resulting in high-titred short-lived viremia, but viral DNA is detectable also in cells of several other types. Recently B19 DNA has been found, by very sensitive amplification tests, in certain tissues not only of symptomatic but also of healthy individuals for several years or decades after B19 infection. The mere presence of 1319 DNA in these tissues of a symptomatic patient (e.g. joints in chronic arthritis or skin in dermatomyositis) thereby does not prove that the present disease is caused by B19. The diagnosis has to be verified by other innovative means. How and why viral DNA persists in the tissues of healthy individuals is under investigation. (C) 2002 Editions scientifiques et medicales Elsevier SAS.