Differential distribution of allelic variants in cytokine genes among African Americans and white Americans
Differential distribution of allelic variants in cytokine genes among African Americans and white Americans
复制标题
DOI：
10.1093/aje/kwh325
复制
发表时间：
2004-12-01
影响因子：
5
通讯作者：
Ferrell, R
中科院分区：
文献类型：
--
作者：
Ness, RB;Haggerty, CL;Ferrell, R
健康方面的种族差异在很大程度上无法解释。由于许多导致非裔美国人过早死亡的疾病是由免疫系统介导的，因此作者探索了已知刺激炎症的细胞因子基因中等位基因变异的种族特异性分布。作者研究了1997-2001年在美国一家医院寻求产前护理和分娩单胎的无并发症的第一胎妇女。共有179名非裔美国妇女和396名白人妇女被评估细胞因子基因中功能相关的等位基因变异。非裔美国女性明显更有可能携带能够上调促炎细胞因子的等位基因变异；优势比随等位基因剂量增加而增加。非裔美国人与白人在基因型上调促炎白细胞介素（IL） 1 （IL1A-4845G/G、IL1A-889T/T、IL1B-3957C/C和IL1B-511A/A）的比值比为2.1 - 4.9。促炎细胞因子白细胞介素-6 IL6-174 G/G基因型在非裔美国人中是前者的36.5倍（95%可信区间（CI）： 8.8, 151.9）。已知下调抗炎白介素-10 （IL10-819 T/T和IL10-1082 A/A）的基因型在非裔美国人中升高了3.5倍（95% CI: 1.8, 6.6）和2.8倍（95% CI: 1.6, 4.9）。在非裔美国女性中发现的细胞因子基因型更常见的是那些上调炎症的基因型。
Racial disparities in health are largely unexplained. Because many diseases causing premature mortality among African Americans are mediated by the immune system, the authors explored the race-specific distribution of allelic variants in cytokine genes known to stimulate inflammation. The authors studied women seeking prenatal care and delivering singletons in uncomplicated first births at a US hospital in 1997-2001. A total of 179 African-American women and 396 White women were evaluated for functionally relevant allelic variants in cytokine genes. African-American women were significantly more likely to carry allelic variants known to up-regulate proinflammatory cytokines; odds ratios increased with allele dose. Odds ratios for African Americans versus Whites in genotypes up-regulating proinflammatory interleukin (IL) 1 (IL1A-4845G/G, IL1A-889T/T, IL1B-3957C/C, and IL1B-511A/A) ranged from 2.1 to 4.9. The proinflammatory cytokine interleukin-6 IL6-174 G/G genotype was 36.5 times (95% confidence interval (CI): 8.8, 151.9) more common among African Americans. Genotypes known to down-regulate the antiinflammatory interleukin-10 (IL10-819 T/T and IL10-1082 A/A) were elevated 3.5-fold (95% CI: 1.8, 6.6) and 2.8-fold (95% CI: 1.6, 4.9) in African Americans. Cytokine genotypes found to be more common in African-American women were consistently those that up-regulate inflammation.