Direct Recordings from Human Anterior Insula Reveal its Leading Role within the Error-Monitoring Network
Direct Recordings from Human Anterior Insula Reveal its Leading Role within the Error-Monitoring Network
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DOI：
10.1093/cercor/bhv352
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发表时间：
2017-02-01
期刊：
影响因子：
3.7
通讯作者：
Jerbi, Karim
中科院分区：
文献类型：
--
作者：
Bastin, Julien;Deman, Pierre;Jerbi, Karim
监控我们自己错误的能力是由一个包括背内侧前额叶皮层（dmPFC）和前脑岛（AI）在内的网络调节的。然而，潜在的神经生理过程的动力学仍然不清楚。特别是，人工智能是在错误监控网络的接收端还是驱动端还没有解决。在这里，我们记录了癫痫患者在执行停止信号任务时同时来自AI和dmPFC的脑内脑电图信号。我们发现错误选择性地调节了人类人工智能中的宽带神经活动。格兰杰因果关系估计显示，人工智能对前扣带皮层的前馈影响紧随错误之后，随后又对前辅助运动区域产生影响。在正确的回答上观察到相反的信息流模式。我们的研究结果提供了第一个直接的电生理学证据，表明前叶岛快速检测并向dmPFC传递错误信号，而后者可能使用这种输入来适应不适当的行为。
The ability to monitor our own errors is mediated by a network that includes dorsomedial prefrontal cortex (dmPFC) and anterior insula (AI). However, the dynamics of the underlying neurophysiological processes remain unclear. In particular, whether AI is on the receiving or driving end of the error-monitoring network is unresolved. Here, we recorded intracerebral electroencephalography signals simultaneously from AI and dmPFC in epileptic patients while they performed a stop-signal task. We found that errors selectively modulated broadband neural activity in human AI. Granger causality estimates revealed that errors were immediately followed by a feedforward influence from AI onto anterior cingulate cortex and, subsequently, onto presupplementary motor area. The reverse pattern of information flow was observed on correct responses. Our findings provide the first direct electrophysiological evidence indicating that the anterior insula rapidly detects and conveys error signals to dmPFC, while the latter might use this input to adapt behavior following inappropriate actions.