Pancreatic and Extrapancreatic Effects of Gastric Inhibitory Polypeptide
Pancreatic and Extrapancreatic Effects of Gastric Inhibitory Polypeptide
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DOI：
10.2337/db06-s011
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发表时间：
2006-12
期刊：
影响因子：
7.7
通讯作者：
Yuichiro Yamada;K. Miyawaki;K. Tsukiyama;N. Harada;C. Yamada;Y. Seino
中科院分区：
文献类型：
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作者：
Yuichiro Yamada;K. Miyawaki;K. Tsukiyama;N. Harada;C. Yamada;Y. Seino
涉及作为从肠道到胰腺β细胞的信号的传递物的激素因子被称为肠促胰岛素，并且胃抑制多肽（GIP）被鉴定为肠促胰岛素之一。GIP是一种42个氨基酸的胃肠肽激素，在吸收葡萄糖或脂肪后从十二指肠内分泌K细胞释放，并通过与其特异性受体GIP受体结合发挥其作用。通过产生和表征具有GIP受体基因的靶向突变的小鼠，我们已经表明GIP不仅具有促胰岛素作用，而且对脂肪积累到脂肪组织和钙积累到骨骼中具有生理作用。我们在这里提出了一个新的缩写，GIP，肠源性营养摄入多肽。
The hormonal factor(s) implicated as transmitters of signals from the gut to pancreatic β-cells is referred to as incretin, and gastric inhibitory polypeptide (GIP) is identified as one of the incretins. GIP is a gastrointestinal peptide hormone of 42 amino acids that is released from duodenal endocrine K-cells after absorption of glucose or fat and exerts its effects by binding to its specific receptor, the GIP receptor. By generating and characterizing mice with a targeted mutation of the GIP receptor gene, we have shown that GIP has not only an insulinotropic role, but also physiological roles on fat accumulation into adipose tissues and calcium accumulation into bone. We here propose a new acronym, GIP, for gut-derived nutrient-intake polypeptide.