Synthesis and characterization of bola-type amphiphilic dendritic macromolecules
Synthesis and characterization of bola-type amphiphilic dendritic macromolecules
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DOI：
10.1021/ma062189q
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发表时间：
2006-12-26
期刊：
影响因子：
5.5
通讯作者：
Grinstaff, Mark W.
中科院分区：
文献类型：
--
作者：
Degoricija, Lovorka;Carnahan, Michael A.;Grinstaff, Mark W.
采用高产率发散法合成了第四代bola型线性树枝状大分子。这些系统是由一个非免疫原性的线性聚（乙二醇）的核心和树枝状楔形的琥珀酸和甘油连接酯键在三嵌段架构。三种分子量PEG（3400、10 000和20 000 g/mol）用于低、中和高分子量大分子的合成。通过MALDI-TOF和SEC测定分子量数据。通过调制差示扫描量热法（MDSC）和荧光光谱法测定的临界聚集浓度（CAC）的大分子进行了进一步表征。使用人脐静脉内皮细胞（HUVEC）进行细胞毒性研究。这些大分子对于各种生物医学应用（包括眼部伤口的修复）是令人感兴趣的。
The synthesis of fourth-generation bola-type linear-dendritic macromolecules is described using a high yielding divergent method. These systems are composed of a non-immunogenic linear poly(ethylene glycol) core and dendritic wedges of succinic acid and glycerol connected by ester linkages in a triblock architecture. Three molecular weight PEGs (3400, 10 000, and 20 000 g/mol) were used in the synthesis of low, medium, and high molecular weight macromolecules. The molecular weight data were determined by MALDI-TOF and SEC. The macromolecules were further characterized by modulated differential scanning calorimetry (MDSC) and critical aggregation concentration (CAC) as determined by fluorescence spectroscopy. Cell toxicity studies were performed with human umbilical vein endothelial cells (HUVEC). These macromolecules are of interest for a variety of biomedical applications including the repair of ocular wounds.