Spontaneous cytogenetic abnormalities in lymphocytes from thirteen patients with ataxia telangiectasia
Spontaneous cytogenetic abnormalities in lymphocytes from thirteen patients with ataxia telangiectasia
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13 例共济失调性毛细血管扩张症患者淋巴细胞自发性细胞遗传学异常
DOI：
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发表时间：
1981
影响因子：
6.4
通讯作者：
J. Metcalfe
中科院分区：
文献类型：
--
作者：
A. Taylor;J. M. Oxford;J. Metcalfe
Ataxia telangiectasia (AT) is a human autosomal recessive disorder in which patients show a marked predisposition to malignant disease and cytogenetic abnormalities. We report here the levels of spontaneously occurring chromosome aberrations and particularly the presence of cytogenetically marked clones of cells in peripheral lymphocytes of 13 patients. There is a variation between the patients with respect to frequency of different aberration types, and clones are present in 5/13 patients. Several of these patients appear to have more than a single clone, possible clones or subclones. There is no evidence for any malignant disease in any of these patients. A description is given from one of these patients, of the most complex clone so far reported in an AT patient without malignant disease. The development of such a complex clone might be important as a step in malignant change. Similarities between this clone and one reported in an AT patient with T‐cell chronic lymphocytic leukaemia are discussed.
