Syntheses and biological evaluations of α-D-mannosyl [60]fullerenols
Syntheses and biological evaluations of α-D-mannosyl [60]fullerenols
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DOI：
10.1016/s0960-894x(01)00583-2
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发表时间：
2001-11-19
影响因子：
2.7
通讯作者：
Shinohara, H
中科院分区：
文献类型：
--
作者：
Kato, H;Yashiro, A;Shinohara, H
[60]Fullerenols carrying mono- and biS-alpha -D-mannosyl linkages on the surface were prepared via a [3 + 2]-cycloaddition reaction between 2-azidoethyl alpha -D-mannoside and C-60 followed by polyhydroxylation. with aqueous NaOH. Their biological activity was evaluated in terms of binding affinity to lectins by hemagglutination assay and surface plasmon resonance. [60]Fullerenols without the mannosyl linkage caused aggregation of erythrocytes and binding to a beta -D-galactopyranoside specific lectin (RCA(120)). In contrast, mono- and bis-mannosyl fullerenols were found to decrease the activity for both aggregating erythrocytes and binding to RCA(120), and mono-mannosyl fullerenols turned to binding to alpha -D-mannose specific lectin (Con A). (C) 2001 Elsevier Science Ltd. All rights reserved.
