Proportion of HIV infections attributable to other sexually transmitted diseases in a rural Ugandan population: simulation model estimates.
Proportion of HIV infections attributable to other sexually transmitted diseases in a rural Ugandan population: simulation model estimates.
复制标题
乌干达农村人口中由其他性传播疾病引起的艾滋病毒感染比例：模拟模型估计。
DOI：
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复制
发表时间：
1997
影响因子：
7.7
通讯作者：
R. Hayes
中科院分区：
文献类型：
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作者：
N. J. Robinson;D. Mulder;B. Auvert;R. Hayes
背景
在其他性传播疾病（STD）存在的情况下，无保护的异性性接触增加了艾滋病毒传播的可能性。这项研究的目的是估计艾滋病毒感染的比例归因于性病在乌干达农村地区。
方法
利用乌干达西南部一个10 000人的特定农村人口队列的数据，对艾滋病毒感染以及溃疡性和非溃疡性性病的传播动态进行了模拟建模，以实现这一目标。
结果
在艾滋病毒流行最初10年（1980-1990年）的模拟中，超过90%的艾滋病毒感染归因于性病。即使对性传播疾病的流行及其对艾滋病毒传播的促进作用作出保守的假设，性传播疾病在艾滋病毒感染的迅速和广泛传播中也发挥了关键作用。性病的作用随着艾滋病毒流行的进展而下降。
结论
在发展中国家，成功的性传播疾病干预方案可能大大有助于控制艾滋病毒感染的蔓延，特别是在艾滋病毒感染尚未确立的地区。
BACKGROUND
Unprotected heterosexual contact in the presence of other sexually transmitted diseases (STD) enhances the probability of HIV transmission. The objective of this study was to estimate the proportion of HIV infections attributable to STD in rural Uganda.
METHODS
Simulation modelling scenarios of the transmission dynamics of HIV infection and of ulcerative and non-ulcerative STD were employed to address this objective, drawing on data from a specific rural population cohort of 10,000 in south-west Uganda.
RESULTS
In simulations of the initial 10-year period of the HIV epidemic (1980-1990), over 90% of HIV infections were attributed to STD. Even given conservative assumptions about the prevalence of STD and about their enhancing effects on HIV transmission, STD played a critical role in the rapid and extensive spread of HIV infection. The role of STD decreased with progression of the HIV epidemic.
CONCLUSIONS
In developing countries, control of the spread of HIV infection may benefit substantially from successful STD intervention programmes, and particularly in areas where HIV infection is not already well established.
影响因子：
158.5
作者：
DAAR, ES;MOUDGIL, T;HO, DD
通讯作者：
HO, DD