OCCUPATIONAL AND ENVIRONMENTAL EXPOSURE TO ARSENIC - INCREASED URINARY ARSENIC LEVEL IN CHILDREN
OCCUPATIONAL AND ENVIRONMENTAL EXPOSURE TO ARSENIC - INCREASED URINARY ARSENIC LEVEL IN CHILDREN
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DOI：
10.1016/0048-9697(91)90258-g
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发表时间：
1991-09-01
影响因子：
9.8
通讯作者：
POULSEN, OM
中科院分区：
文献类型：
--
作者：
JENSEN, GE;CHRISTENSEN, JM;POULSEN, OM
对生活在未受砷污染地区的成人和儿童的尿中无机砷、甲基胂酸（MMAA）和二甲基胂酸（DMAA）的浓度之和与生活在砷污染地区的成人和儿童的尿中无机砷、甲基胂酸（MMAA）和二甲基胂酸（DMAA）的浓度之和以及职业接触砷的人的尿中无机砷、甲基胂酸和二甲基胂酸的浓度之和进行了比较。 22名成人和10名儿童，年龄在3-10岁，生活在未受污染的地区的中位数分别为9.3和19.8 nmol砷/mmol肌酐。 相应的范围分别为3.2-27.9和7.7-57.8 nmol As/mmol肌酐。 成人和儿童之间的差异通过Mann-Whitney非参数检验进行检验，发现具有显著性（p < 0.0025）。 污染区73名成人和10名儿童尿砷浓度与非污染区尿砷浓度无显著性差异。 处理砷处理过的木材的成年工人尿液中的砷含量大约高出4倍（p < 0.001），最大记录浓度对应于814.9 nmol As/mmol肌酐。 两名玻璃工人尿液中的砷含量分别高出9倍和2倍。 浸木工人和铅蓄电池工人的尿中砷含量没有显著增加。
The sum of concentrations of inorganic arsenic, methylarsonic acid (MMAA) and dimethyl-arsinic acid (DMAA) in urine from adults and children living in an unpolluted area was compared with the corresponding sum measured in urine from adults and children living in an area polluted with arsenic and in urine from persons occupationally exposed to arsenic. The median values for 22 adults and 10 children aged 3-10 years living in the unpolluted area were 9.3 and 19.8 nmol As/mmol creatinine, respectively. The corresponding ranges were 3.2-27.9 and 7.7-57.8 nmol As/mmol creatinine, respectively. The difference between adults and children was tested by Mann-Whitney's non-parametric test and found to be significant (p < 0.0025). No significant difference was found in arsenic concentration in urine from 73 adults and 10 children living in the polluted area compared with the arsenic concentration in urine from those living in the unpolluted area. The arsenic level in urine from adult workers handling arsenic-treated wood was approximately four-fold higher (p < 0.001), with a maximum recorded concentration corresponding to 814.9 nmol As/mmol creatinine. The arsenic levels in urine from two glass workers were nine- and two-fold higher, respectively. No significantly increased arsenic levels were found in urine from workers impregnating wood and in urine from lead accumulator workers.