Electronic pill-boxes in the evaluation of antihypertensive treatment compliance:: Comparison of once daily versus twice daily regimen
Electronic pill-boxes in the evaluation of antihypertensive treatment compliance:: Comparison of once daily versus twice daily regimen
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DOI：
10.1016/s0895-7061(99)00175-2
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发表时间：
2000-02-01
影响因子：
3.2
通讯作者：
Carré, A
中科院分区：
文献类型：
--
作者：
Andrejak, M;Genes, N;Carré, A
目的是比较高血压患者服用卡托普利每日两次或群多普利每日一次的依从性。在2周的安慰剂治疗期后，高血压患者（舒张压95-115 mm Hg）被随机分配到群多普利2 mg每日一次或卡托普利25 mg每日两次治疗6个月。将群多普利和卡托普利包装在装有微处理器的电子药盒中，微处理器记录每次打开的日期和时间（MEMS（R））。通过标准药丸计数和电子监测评估患者的依从性。在安慰剂期和治疗期结束时，使用经过验证的半自动装置测量血压。133例患者的依从性数据可评价（62例在卡托普利组，71例在群多普利组）。除年龄外，治疗组在基线时相当（P = .046）。使用电子药盒，群多普利组和卡托普利组的总体依从性分别为98.9%和97.5%（P = .002）。漏服率在群多普利组为2.6%，在卡托普利组为3.3%（P = 0.06）。群多普利组和卡托普利组延迟给药的百分比分别为1.8%和11.7%（P = 0.0001）。群多普利组和卡托普利组的正确给药周期（即只有一个正确记录的开放周期）的百分比分别为94.0%和78.1%（P = 0.0001）。当调整年龄时，结果没有变化。研究结束时，群多普利组41%的患者和卡托普利组（NS）27%的患者血压正常（收缩压
The objective was to compare the compliance of hypertensive patients treated with captopril twice daily or trandolapril once daily. After a 2-week placebo period, hypertensive patients (diastolic BP 95-115 mm Hg) were randomly allocated to trandolapril 2 mg once daily or to captopril 25 mg twice daily for 6 months. Trandolapril and captopril were packed in electronic pill-boxes equipped with a microprocessor that recorded date and time of each opening (MEMS(R)). Patients' compliance was assessed both by standard pill-count and by electronic monitoring. Blood pressure was measured using a validated semi-automatic device at the end of the placebo period and of the treatment period.One hundred sixty-two patients entered the study. Compliance data were evaluable for 133 patients (62 in the captopril group and 71 in the trandolapril group). Treatment groups were comparable at baseline except for age (P = .046). Using electronic pill-box, overall compliance was 98.9% in the trandolapril group and 97.5% in the captopril group (P = .002). The percentage of missed doses was 2.6% in the trandolapril group and 3.3% in the captopril group (P =.06). The percentage of delayed doses was 1.8% in the trandolapril group and 11.7% in the captopril group (P = .0001).The percentage of correct dosing periods, ie, a period with only one correct recorded opening, was 94.0% in the trandolapril group and 78.1% in the captopril group (P = .0001). Results were unchanged when adjusted for age. At the end of the study, 41% of patients in the trandolapril group and 27% in the captopril group (NS) had their blood pressure normalized (systolic BP