THE APPROACHING ERA OF THE TUMOR SUPPRESSOR GENES
THE APPROACHING ERA OF THE TUMOR SUPPRESSOR GENES
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DOI：
10.1126/science.3317834
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发表时间：
1987-12-11
期刊：
影响因子：
56.9
通讯作者：
KLEIN, G
中科院分区：
文献类型：
--
作者：
KLEIN, G
通过正常细胞和恶性细胞的融合、体外转化体的表型逆转、恶性细胞谱系的终末分化的诱导、“隐性癌基因”的丢失、在某些癌基因附近发现调节序列以及正常细胞产物对肿瘤生长的抑制，已经检测到可以抑制致瘤表型表达的基因。这些肿瘤抑制基因可能会像癌基因一样多样化，如果不是更多的话。考虑这两种基因可能揭示共同或相关的功能特性。
Genes that can inhibit the expression of the tumorigenic phenotype have been detected by the fusion of normal and malignant cells, the phenotypic reversion of in vitro transformants, the induction of terminal differentiation of malignant cell lineages, the loss of "recessive cancer genes," the discovery of regulatory sequences in the immediate vicinity of certain oncogenes, and the inhibition of tumor growth by normal cell products. Such tumor suppressor genes will probably turn out to be as, if not more, diversified as the oncogenes. Consideration of both kinds of genes may reveal common or interrelated functional properties.