Prevalence of Active Syphilis Infection and Risk Factors among HIV-Positive MSM in Zhejiang, China in 2015: A Cross-Sectional Study
Prevalence of Active Syphilis Infection and Risk Factors among HIV-Positive MSM in Zhejiang, China in 2015: A Cross-Sectional Study
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DOI：
10.3390/ijerph16091507
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发表时间：
2019-05-01
影响因子：
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通讯作者：
Pan, Xiaohong
中科院分区：
文献类型：
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作者：
Chen, Lin;Yang, Jiezhe;Pan, Xiaohong
目的：了解2015年浙江省HIV阳性男男性行为者（MSM）活动性梅毒感染情况，探讨活动性梅毒的危险因素。设计：2015年6月至12月，从国家性艾中心和浙江省艾滋病性病监测系统获取居住在浙江省的HIV阳性MSM数据。行为、被诊断出艾滋病毒的年数以及高效抗逆转录病毒治疗 (HAART)。使用SPSS 19.0进行数据分析。结果：分析包括 3616 个 MSM。其中，11.3% (407/3616) 患有活动性梅毒。多变量逻辑回归分析显示，HAART 与活动性梅毒感染风险增加显着相关（比值比 (OR) = 1.760，95% 置信区间 (CI) 1.187-2.611）。与确诊感染艾滋病毒5年的参与者相比，活动性梅毒感染的风险更高（OR = 1.707，95% CI 1.167-2.495）。年龄和性伴侣数量也是活动性梅毒感染的独立危险因素。结论：浙江省HIV阳性男男性接触者活动性梅毒感染发生率较高；年龄、性伴侣数量、感染艾滋病毒的年数以及接受高效抗逆转录病毒疗法（HAART）是危险因素。老年患者、HIV感染者生活时间较长、性伴侣较多以及接受HAART治疗的患者应成为干预措施的重点，以促进行为改变，减少梅毒感染。
Objectives: To determine the prevalence of active syphilis infection and explore the risk factors for active syphilis in human immunodeficiency virus (HIV)-positive men who had sex with men (MSM) in Zhejiang Province, 2015. Design: Data on HIV-positive MSM living in Zhejiang Province were obtained from the National Center for AIDS/STD Control and Prevention (NCAIDS) reporting system and the Zhejiang provincial AIDS/STD surveillance system between June and December 2015. The information included risky behavior, years with diagnosed HIV, and highly active antiretroviral therapy (HAART). SPSS 19.0 was used for the data analysis. Results: The analysis included 3616 MSM. Of these, 11.3% (407/3616) had active syphilis. Multivariate logistic regression analysis revealed that HAART was significantly associated with an increased risk of active syphilis infection (odds ratio (OR) = 1.760, 95% confidence interval (CI) 1.187-2.611). Compared with participants diagnosed with HIV for 5 years had a higher risk of active syphilis infection (OR = 1.707, 95% CI 1.167-2.495). Age and number of sex partners were also independent risk factors for active syphilis infection. Conclusions: The incidence of active syphilis infection is high among HIV-positive MSM in Zhejiang Province; age, number of sex partners, years with diagnosed HIV, and receiving HAART were risk factors. Patients who are elderly, have lived with HIV for a longer period, have more sex partners, and receive HAART should be the focus of interventions to promote changes in behavior and decrease syphilis infection.