Catestatin is useful in detecting patients with stage B heart failure
Catestatin is useful in detecting patients with stage B heart failure
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DOI：
10.3109/1354750x.2011.629058
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发表时间：
2011-12-01
期刊：
影响因子：
2.6
通讯作者：
Gao, Wei
中科院分区：
文献类型：
--
作者：
Zhu, Dan;Wang, Fangfang;Gao, Wei
筛查B期心力衰竭（HF）患者可能是降低人类发病率的一种策略。为了描述不同阶段HF中的catestatin水平，并评估catestatin检测B期HF的诊断效用，我们纳入了300例患者。进行Catestatin、BNP检测和超声心动图检查。我们的研究表明，从A期到C期，catestatin逐渐下降。A期与B期之间有显著性差异。catestatin检测B期HF的临界值为19.73 ng/ml，敏感性为90%，特异性为50.9%。这些结果可能对检测B期HF患者的新方法有意义。
Screening patients with stage B heart failure(HF) may be one strategy for reducing human morbidity. To describe catestatin levels in different stages of HF and evaluate the diagnostic utility of catestatin for detecting stage B HF, we included 300 patients. Catestatin, BNP testing and echocardiogram were performed. Our studies showed catestatin decreased gradually from stage A to C. There was significant difference between stage A and B. Cutoff value for detecting stage B HF was 19.73 ng/ml for catestatin with 90% sensitivity and 50.9% specificity. These results may have implications in the new method to detect patients with stage B HF.