Individual oral symptoms in burning mouth syndrome may be associated differentially with depression and anxiety
Individual oral symptoms in burning mouth syndrome may be associated differentially with depression and anxiety
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DOI：
10.3109/00016357.2015.1100324
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发表时间：
2016-02-17
影响因子：
2
通讯作者：
Prime, Stephen S.
中科院分区：
文献类型：
--
作者：
Davies, Simon J. C.;Underhill, Helen C.;Prime, Stephen S.
灼口综合征（BMS）是一种以口腔灼烧感为特征的特发性疾病。到口腔医学诊所就诊的患者中有10%患有BMS。焦虑和抑郁是BMS常见的合并症，但尚不清楚它们是否与特定的BMS症状相关。目的通过探索性分析，研究广泛性焦虑和抑郁与个体BMS症状的关系。方法从某口腔门诊招募41例BMS患者（30例BMS患者，11例其他口腔疾病患者），评估BMS特异性症状及其强度。焦虑和抑郁症状评估使用标准化的措施（临床访谈时间表-修订）。结果味觉改变（p=0.007）、对严重疾病的恐惧（p=0.011）、金属味（p=0.018）和牙龈膜感（p=0.047）与精神症状的过度相关。更具体地说，金属味（系数=0.497,95% CI=0.149-0.845, p=0.006）和牙龈膜感（系数=0.625,95% CI=0.148-1.103, p=0.012）与抑郁症状得分较高显著相关；味觉变化（系数=0.269,95% CI=0.077-0.461; p=0.007）、口臭（系数=0.273,95% CI=0.065-0.482; p=0.012）和对严重疾病的恐惧（系数=0.242,95% CI=0.036-0.448; p=0.023）与较高的焦虑得分相关。结论BMS特异性症状与广泛性焦虑和抑郁存在差异。牙科医生应确定哪些BMS症状是主要的，并注意某些症状与焦虑或抑郁的关系，如有必要，应考虑进行医疗咨询。
Background Burning mouth syndrome (BMS) is an idiopathic disease characterized by the feeling of burning in the oral cavity. Ten per cent of patients presenting to oral medicine clinics have BMS. Anxiety and depression are common co-morbidities in BMS, but it is not known if they are associated with specific BMS symptoms. Objective In an exploratory analysis, this study examined the association of generalized anxiety and depression with individual BMS symptoms. Methods Forty-one patients were recruited from a dental outpatient clinic (30 with BMS and 11 with other oral conditions), evaluating specific BMS symptoms and their intensity. Anxiety and depression symptoms were assessed using a standardized measure (Clinical Interview Schedule-Revised). Results Taste change (p=0.007), fear of serious illness (p=0.011), metallic taste (p=0.018) and sensation of a film on the gums (p=0.047) were associated with an excess of psychiatric symptoms. More specifically, metallic taste (coefficient=0.497, 95% CI=0.149-0.845; p=0.006) and sensation of film on gums (coefficient=0.625, 95% CI=0.148-1.103; p=0.012) were associated significantly with higher scores for depressive symptoms; taste change (coefficient=0.269, 95% CI=0.077-0.461; p=0.007), bad breath (coefficient=0.273, 95% CI=0.065-0.482; p=0.012) and fear of serious illness (coefficient=0.242, 95% CI=0.036-0.448; p=0.023) were associated with higher anxiety scores. Conclusion Specific BMS symptoms are associated differentially with generalized anxiety and depression. Dental practitioners should ascertain which BMS symptoms are predominant and be mindful of the association of certain symptoms with anxiety or depression and, where necessary, consider medical consultation.