Dynamic changes in acetylcholine output in the medial striatum during place reversal learning.
Dynamic changes in acetylcholine output in the medial striatum during place reversal learning.
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DOI：
10.1101/lm.65404
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发表时间：
2004
影响因子：
2
通讯作者：
M. Ragozzino;D. Choi
中科院分区：
文献类型：
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作者：
M. Ragozzino;D. Choi
本研究探讨了任务偶然性变化时内侧纹状体在学习中的作用。实验一探讨内侧纹状体是否参与位置反转学习。测试在两个连续阶段的改良十字迷宫中进行。注射局部麻醉药布比卡因，进入内侧纹状体，并没有损害的地方收购，但受损的地方逆转学习。反向学习缺陷是由于在最初的转变之后无法保持新的选择模式。实验2确定乙酰胆碱（ACh）输出的变化是否发生在收购或逆转学习的地方歧视。在行为测试过程中，使用体内微透析，以6分钟的间隔收集样本，评估内侧纹状体的细胞外ACh输出。乙酰胆碱输出没有改变，从基础水平在收购的地方。在逆转学习过程中，乙酰胆碱输出显着增加大鼠开始学习新的选择模式，并返回到附近的基础水平作为一个大鼠可靠地执行新的位置策略。目前的研究结果表明，内侧纹状体可能是关键的灵活适应涉及空间信息，乙酰胆碱在这方面的行动，使选择模式的转变时，环境条件的变化。
The present studies explored the role of the medial striatum in learning when task contingencies change. Experiment 1 examined whether the medial striatum is involved in place reversal learning. Testing occurred in a modified cross-maze across two consecutive sessions. Injections of the local anesthetic, bupivacaine, into the medial striatum, did not impair place acquisition, but impaired place reversal learning. The reversal-learning deficit was due to an inability to maintain the new choice pattern following the initial shift. Experiment 2 determined whether changes in acetylcholine (ACh) output occur during the acquisition or reversal learning of a place discrimination. Extracellular ACh output from the medial striatum was assessed in samples collected at 6-min intervals using in vivo microdialysis during behavioral testing. ACh output did not change from basal levels during place acquisition. During reversal learning, ACh output significantly increased as rats began to learn the new choice pattern, and returned to near basal levels as a rat reliably executed the new place strategy. The present results suggest that the medial striatum may be critical for flexible adaptations involving spatial information, and that ACh actions in this area enable the shifting of choice patterns when environmental conditions change.