The dysregulated Pink1(-) Drosophila mitochondrial proteome is partially corrected with exercise.
The dysregulated Pink1(-) Drosophila mitochondrial proteome is partially corrected with exercise.
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Pink 1（-）果蝇线粒体蛋白质组失调部分纠正运动。
DOI：
10.18632/aging.203128
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发表时间：
2021-06-01
期刊：
影响因子：
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通讯作者：
Chakrabarti L
中科院分区：
文献类型：
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作者：
Ebanks B;Ingram TL;Katyal G;Ingram JR;Moisoi N;Chakrabarti L
与青少年/早发性帕金森病（PD）发病有关的基因之一是PINK 1。有证据支持运动在缓解PD症状方面的治疗潜力。运动可能会增强突触可塑性，保护神经炎症和调节L-Dopa调节的信号通路。本研究探讨了运动对Pink 1基因缺陷型果蝇神经退行性变和肌肉退行性变的影响。我们使用了一个“电力塔”型的运动平台，提供运动活动的粉红色1和年龄匹配的野生型果蝇。线粒体蛋白质组学谱响应运动。在鉴定的516种蛋白质中，有105种蛋白质在Pink 1和野生型未运动果蝇之间具有不同的水平。基因本体富集分析和STRING网络分析突出了线粒体蛋白质组内表达改变的蛋白质和途径。Pink 1-行使蛋白质组与野生型蛋白质组的比较表明，行使Pink 1-果蝇导致他们的蛋白质组图谱恢复到野生型水平。
One of the genes which has been linked to the onset of juvenile/early onset Parkinson’s disease (PD) is PINK1. There is evidence that supports the therapeutic potential of exercise in the alleviation of PD symptoms. It is possible that exercise may enhance synaptic plasticity, protect against neuro-inflammation and modulate L-Dopa regulated signalling pathways. We explored the effects of exercise on Pink1 deficient Drosophila melanogaster which undergo neurodegeneration and muscle degeneration. We used a ‘power-tower’ type exercise platform to deliver exercise activity to Pink1- and age matched wild-type Drosophila. Mitochondrial proteomic profiles responding to exercise were obtained. Of the 516 proteins identified, 105 proteins had different levels between Pink1- and wild-type non-exercised Drosophila. Gene ontology enrichment analysis and STRING network analysis highlighted proteins and pathways with altered expression within the mitochondrial proteome. Comparison of the Pink1- exercised proteome to wild-type proteomes showed that exercising the Pink1- Drosophila caused their proteomic profile to return towards wild-type levels.