Prevalence and clinical correlates of dementia among COVID-19-related deaths in Italy.
Prevalence and clinical correlates of dementia among COVID-19-related deaths in Italy.
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DOI：
10.1002/dad2.12114
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发表时间：
2020
期刊：
影响因子：
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通讯作者：
Italian National Institute of Health COVID‐19 Mortality Group*
中科院分区：
文献类型：
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作者：
Canevelli M;Palmieri L;Raparelli V;Lo Noce C;Colaizzo E;Tiple D;Vaianella L;Vanacore N;Brusaferro S;Onder G;Italian National Institute of Health COVID‐19 Mortality Group*
我们的目标是探索意大利死于新冠肺炎和伴随痴呆症的患者的比例，以及他们的临床特征和护理轨迹。通过考虑意大利医院死亡的代表性样本(n=2621)的病历，探索了与新冠肺炎相关的死亡发生在痴呆症患者中的比例，以及根据痴呆症状态去世的个人的临床特征。在研究人群中总共发现了415名痴呆症患者，占新冠肺炎相关死亡总人数的15.8%。与认知完整的人相比，痴呆症患者较少出现咳嗽，接受支持性治疗和重症监护方法的机会较低，临床恶化速度更快。在SARS-CoV-2感染的情况下，痴呆症具有相关的不良后果风险，并影响受影响个人的临床表现、病程和管理。
We aimed at exploring the proportion of patients dying with COVID‐19 and concomitant dementia in Italy, as well as their clinical characteristics and trajectories of care. The proportion of COVID‐19‐related deaths occurring in people with dementia and the clinical characteristics of deceased individuals according to their dementia status were explored by considering the medical charts of a representative sample of patients deceased in Italian hospitals (n = 2621). A total of 415 individuals with dementia were identified in the study population, accounting for 15.8% of overall COVID‐19‐related deaths. Patients with dementia less frequently presented with cough, had lower chance of receiving supportive therapies and intensive care approaches, and showed a faster clinical worsening as compared with individuals with intact cognition. Dementia confers a relevant risk of adverse outcomes in case of SARS‐CoV‐2 infection and influences the clinical presentation, course and management of affected individuals.