Effects of social isolation on brain catecholamines and forced swimming in rats: prevention by antidepressant treatment.
Effects of social isolation on brain catecholamines and forced swimming in rats: prevention by antidepressant treatment.
复制标题
社会隔离对大鼠脑儿茶酚胺和强迫游泳的影响：通过抗抑郁治疗预防。
DOI：
10.1016/0022-3956(90)90014-h
复制
发表时间：
1990
影响因子：
4.8
通讯作者：
Westfall,TC
中科院分区：
文献类型：
--
作者：
Heritch,AJ;Henderson,K;Westfall,TC
断奶后的大鼠单独或成群饲养4或8周。在此期间，部分动物接受了三环类抗抑郁药物治疗，地塞帕明20 mg/kg/d。然后通过强迫游泳来测试动物的行为。隔离与强迫游泳期间明显更长的不动时间有关。这一作用被地塞帕明治疗所阻断。地塞帕明治疗对群养大鼠的游泳持续时间没有显著影响。随后测量了后脑和中脑中儿茶酚胺的水平，并通过给予α-甲基-对酪氨酸或生理盐水来估计周转率。被隔离的大鼠的儿茶酚胺水平增加，周转减少。去甲肾上腺素水平的增加但不能被地塞帕明阻断，而这种方法不能测试抗抑郁对周转的影响。因此，社会刺激的减少似乎与儿茶酚胺释放的减少有关，儿茶酚胺的释放可能导致这些递质在中枢神经系统中积累。地塞帕明的治疗似乎基本上补偿了减少的社会刺激，阻断了隔离诱导的去甲肾上腺素能神经化学变化，而对对照动物几乎没有显著影响。这项研究可能有助于我们进一步了解生物体与环境的相互作用如何影响儿茶酚胺系统，以及抗抑郁药物如何发挥作用恢复功能。
Post-weaning rats were housed alone or in groups for a period of 4 or 8 weeks. A portion of the animals received tricyclic antidepressant treatment, desipramine 20 mg/kg/day, during this period. Animals were then tested behaviorally by forced swimming. Isolation was associated with significantly longer durations of immobility during forced swimming. This was blocked by desipramine treatment. Desipramine treatment did not have a significant effect on the swimming durations of group-housed rats. Hindbrain and midbrain levels of catecholamines were subsequently measured and turnover rates estimated by administration of α-methyl-p-tyrosine or saline. Isolated rats had increased levels and decreased turnover of catecholamines. The increase in norepinephrine but not dopamine levels was blocked by desipramine, while antidepressant effects on turnover could not be tested with this method. Reduced social stimulation thus appears to be associated with reduced catecholamine release which may result in the accumulation of these transmitters in the central nervous system. Treatment with desipramine appeared essentially to compensate for reduced social stimulation, blocking isolation-induced noradrenergic neurochemical changes, while having few significant effects on control animals. This study may be helpful in furthering our understanding of how the interaction of organisms with their environment influence catecholamine systems and how antidepressants may act to restore function.