Imipenem resistance among Acinetobacter baumannii: Association with reduced expression of a 33-36 kDa outer membrane protein
Imipenem resistance among Acinetobacter baumannii: Association with reduced expression of a 33-36 kDa outer membrane protein
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DOI：
10.1093/jac/38.2.245
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发表时间：
1996-08-01
影响因子：
5.2
通讯作者：
Clark, RB
中科院分区：
文献类型：
--
作者：
Clark, RB
本研究对两株鲍曼不动杆菌（A-1和A-24）的亚胺培南耐药机制进行了研究。分离株A-1的自发回复突变体（A-1（rev））对亚胺培南敏感。β-内酰胺酶水解研究表明，在A-1、A-24、A-1（rev）或其他两种亚胺培南敏感的A.鲍曼不动杆菌分离株。外膜蛋白（OMP）分析表明，与A-1（rev）和其他鲍曼不动杆菌分离株相比，分离株A-1和A-24的33-36 kDa蛋白表达降低。总之，33-36 kDa外膜蛋白表达的降低与A.鲍曼不动杆菌。
The mechanism of imipenem resistance of two Acinetobacter baumannii isolates (A-1 and A-24) was characterized in this study. A spontaneous revertant (A-1 (rev)) derived from isolate A-1 showed susceptibility to imipenem. beta-Lactamase hydrolysis studies showed no evidence of an imipenem hydrolyzing enzyme among A-1, A-24, A-1 (rev), or two other imipenem susceptible A. baumannii isolates. Outer membrane protein (OMP) analysis indicated decreased expression of a 33-36 kDa protein by isolates A-1 and A-24 when compared with A-1 (rev) and the other A, baumannii isolates. In conclusion, decreased expression of a 33-36 kDa OMP is associated with imipenem resistance among A. baumannii.