Distinct Functions of Neutrophil in Cancer and Its Regulation.
Distinct Functions of Neutrophil in Cancer and Its Regulation.
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DOI：
10.1155/2015/701067
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发表时间：
2015
影响因子：
4.6
通讯作者：
Jablonska J
中科院分区：
文献类型：
--
作者：
Granot Z;Jablonska J
中性粒细胞是人体循环中最丰富的白细胞，通常与炎症和抗感染有关。近年来，免疫细胞在癌症中的作用日益引起人们的兴趣。在这种情况下，中性粒细胞的功能是有争议的，因为中性粒细胞被证明具有促进肿瘤和限制肿瘤的特性。在这里，我们提供了中性粒细胞具有的促肿瘤和抗肿瘤特性以及调节这些不同功能的环境线索的最新综述。
Neutrophils are the most abundant of all white blood cells in the human circulation and are usually associated with inflammation and with fighting infections. In recent years the role immune cells play in cancer has been a matter of increasing interest. In this context the function of neutrophils is controversial as neutrophils were shown to possess both tumor promoting and tumor limiting properties. Here we provide an up-to-date review of the pro- and antitumor properties neutrophils possess as well as the environmental cues that regulate these distinct functions.