Attractor dynamics in local neuronal networks.

Attractor dynamics in local neuronal networks.
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DOI:
10.3389/fncir.2014.00022
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发表时间:
2014
影响因子:
3.5
通讯作者:
Longtin A
Longtin A
中科院分区:
医学3区
文献类型:
--
作者:
Thivierge JP;Comas R;Longtin A

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在大脑的各个区域中的突触连接模式的特征在于突触基序的存在,其被定义为遵循特定配置并将小的神经元组链接在一起的单向和双向突触接触。最近的计算工作提出,中继网络(两个群体通过第三个中继神经元群体进行通信)可以产生精确的神经同步模式。在这里,我们采用了两种不同的模型的神经元动力学和模拟的神经电路设计,以这种方式被困在一个全球性的吸引活动,防止神经元调制他们的反应的基础上传入的刺激。为了避免出现一个固定的全局吸引子,我们提出了一种机制,选择性增益抑制,促进灵活的对外部刺激的反应。我们认为,当地的神经元回路可能会采用这种机制,以产生精确的神经同步模式,其短暂的性质界定了一个简短的刺激的发生。
Patterns of synaptic connectivity in various regions of the brain are characterized by the presence of synaptic motifs, defined as unidirectional and bidirectional synaptic contacts that follow a particular configuration and link together small groups of neurons. Recent computational work proposes that a relay network (two populations communicating via a third, relay population of neurons) can generate precise patterns of neural synchronization. Here, we employ two distinct models of neuronal dynamics and show that simulated neural circuits designed in this way are caught in a global attractor of activity that prevents neurons from modulating their response on the basis of incoming stimuli. To circumvent the emergence of a fixed global attractor, we propose a mechanism of selective gain inhibition that promotes flexible responses to external stimuli. We suggest that local neuronal circuits may employ this mechanism to generate precise patterns of neural synchronization whose transient nature delimits the occurrence of a brief stimulus.
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