Evaluation of myocardial, hepatic, and renal perfusion in a variety of clinical conditions using an intravenous ultrasound contrast agent (Optison) and second harmonic imaging
Evaluation of myocardial, hepatic, and renal perfusion in a variety of clinical conditions using an intravenous ultrasound contrast agent (Optison) and second harmonic imaging
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DOI：
10.1136/hrt.81.6.636
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发表时间：
1999-06-01
期刊：
影响因子：
5.7
通讯作者：
Monaghan, MJ
中科院分区：
文献类型：
--
作者：
Hancock, J;Dittrich, H;Monaghan, MJ
目的：评价静脉注射第二代超声造影剂Optison和不同的超声成像模式对正常人和左心功能不全或慢性肺病合并肾、肝功能不全患者的心肌、肾脏和肝脏血流灌注的影响。方法5名正常人和20例患者在静脉注射Optison 505次的过程中进行了心肌、肾脏和肝脏的灰阶超声心动图成像。由两个独立的观察者对图像进行定性评估，并使用视频密度计进行定量，以确定峰值对比度增强效果。定性分析结果表明，对于所有器官，间歇谐波成像均优于传统的基波成像和连续谐波成像。定量分析显示，在连续谐波成像过程中，超声心动图强度v基线的峰值变化为心肌11个单位(p<；0.03)、肾脏7个单位(p<；0.05)和肝脏14个单位(p<；0.05)。在间歇谐波成像中，峰值变化明显更大，心肌为33个单位(p<；0.0001)，肾脏为24个单位(p<；0.0002)，肝脏为16个单位(p<；0.001)。这种造影剂在各种临床条件下都有效。
Objective-To assess the potential of intravenous Optison, a second generation ultrasound contrast agent, and various ultrasound imaging modes to determine myocardial, kidney, and liver perfusion in normal subjects and patients with left ventricular dysfunction or chronic pulmonary disease together with renal or hepatic dysfunction.Methods-Five normal subjects and 20 patients underwent grey scale echocardiographic imaging of myocardium, kidney, and liver during 505 intravenous injections of Optison. Images were assessed qualitatively by two independent observers and quantitatively using video densitometry to determine the peak contrast enhancement effect.Results-Qualitative analysis showed that intermittent harmonic imaging was superior to either conventional fundamental or continuous harmonic imaging for all organs. Quantitative analysis showed that the peak change in echocardiographic intensity v baseline during continuous harmonic imaging was 11 units for myocardium (p < 0.03), 7 units for kidney (NS), and 14 units for Liver (p < 0.05). During intermittent harmonic imaging the peak change was significantly greater, being 33 units for myocardium (p < 0.0001), 24 units for kidney (p < 0.0002), and 16 units for liver (p < 0.001).Conclusions-Organ tissue perfusion can be demonstrated following intravenous injection of Optison, particularly when used in combination with intermittent harmonic imaging techniques. This contrast agent is effective in a variety of clinical conditions.