Enteroglial cells act as antigen-presenting cells in chagasic megacolon
Enteroglial cells act as antigen-presenting cells in chagasic megacolon
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DOI：
10.1016/j.humpath.2010.06.016
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发表时间：
2011-04-01
期刊：
影响因子：
3.3
通讯作者：
Brehmer, Axel
中科院分区：
文献类型：
--
作者：
Morais da Silveira, Alexandre Barcelos;de Oliveira, Enio C.;Brehmer, Axel
恰加斯病是拉丁美洲最严重的寄生虫病之一。其社会和经济影响远远超过其他寄生虫病如疟疾、利什曼病和血吸虫病的综合影响。在这种疾病的慢性阶段，肠神经系统成分的破坏导致巨结肠的发展。除神经元外，肠神经系统由肠神经胶质细胞构成，代表胃肠道内广泛但描述相对较少的群体。一些证据表明，肠神经胶质细胞代表中枢神经系统星形胶质细胞的等价物。先前的数据表明，在肠道炎症和免疫反应期间，肠神经系统中的肠胶质细胞和神经元是活跃的。为了评估这些细胞是否作为抗原呈递细胞，我们研究了负责活化T细胞的分子的表达，如HLA-DR复合物II类和共刺激分子（CD 80和CD 86），由神经元和肠神经胶质细胞。我们的研究结果表明，只有肠dial细胞的chagglutinase患者巨结肠表达HLA-DR复合物II类和共刺激分子，因此，他们提出了必要的属性，作为抗原呈递细胞。(C)2011 Elsevier Inc. All rights reserved.
Chagas disease is one of the most serious parasitic diseases of Latin America. with a social and economic impact far outweighing the combined effects of other parasitic diseases such as malaria, leishmaniasis, and schistosomiasis. In the chronic phase of this disease, the destruction of enteric nervous system components leads to megacolon development. Besides neurons, the enteric nervous system is constituted by enteric glial cells, representing an extensive but relatively poorly described population within the gastrointestinal tract. Several lines of evidence suggest that enteric glial cells represent an equivalent of central nervous system astrocytes. Previous data suggest that enteric glia and neurons are active in the enteric nervous system during intestinal inflammatory and immune responses. To evaluate whether these cells act as antigen-presenting cells, we investigated the expression of molecules responsible for activation of T cells, such as HLA-DR complex class II and costimulatory molecules (CD80 and CD86), by neurons and enteric glial cells. Our results indicate that only enteric dial cells of chagasic patients with megacolon express HLA-DR complex class II and costimulatory molecules, and hence they present the attributes necessary to act as antigen-presenting cells. (C) 2011 Elsevier Inc. All rights reserved.