Low-resolution brain electromagnetic tomography revealed simultaneously active frontal and parietal sleep spindle sources in the human cortex
Low-resolution brain electromagnetic tomography revealed simultaneously active frontal and parietal sleep spindle sources in the human cortex
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DOI：
10.1016/s0306-4522(01)00028-8
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发表时间：
2001-01-01
期刊：
影响因子：
3.3
通讯作者：
Saletu, B
中科院分区：
文献类型：
--
作者：
Anderer, P;Klösch, G;Saletu, B
对头皮记录的睡眠纺锤波的分析表明，纺锤波在地形图上有明显的慢波和快波。本文利用低分辨率电磁层析成像技术，对不同类型睡眠纺锤体对应的脑电活动进行了研究。在其新的实现中，该方法基于逼真的头部几何形状，并且解空间仅限于大脑皮层灰质和海马体。在多导通宵脑电记录中，在10例20~35岁正常人的脑电记录中，观察到10-20个无伪影的1.25-S时期，其纺锤波在额叶、顶叶和大致均匀分布。作为对照条件，标记了S在相应的纺锤波发作前后的1-3个无伪影的非纺锤波时代。低分辨率电磁断层扫描显示，与头皮分布无关，前额叶皮质(Brodmann区9和10区)和楔前叶(Brodmann区7区)有分布的纺锤源，振荡频率低于13赫兹，振荡频率高于13赫兹。在极少数情况下，只有前额或顶叶来源是活跃的。Brodmann区9和10与丘脑背内侧核有主要联系，Brodmann区7与丘脑板内外侧核、背外侧核和头端中央外侧核相连。因此，大脑皮质区域与产生睡眠纺锤体的丘脑背侧相邻部分直接相连。结果同时显示，活跃的皮质纺锤体源频率相差约2赫兹，位于已知参与感觉输入处理的大脑区域，这与睡眠纺锤体的假定功能角色一致。(C)2001年IBRO。爱思唯尔科学有限公司出版。版权所有。
Analyses of scalp-recorded sleep spindles have demonstrated topographically distinct slow and fast spindle waves. In the present paper, the electrical activity in the brain corresponding to different types of sleep spindles was estimated by means of low-resolution electromagnetic tomography. In its new implementation, this method is based on realistic head geometry and solution space is restricted to the cortical gray matter and hippocampus. In multichannel all-night electroencephalographic recordings, 10-20 artifact-free 1.25-s epochs with frontally, parietally and approximately equally distributed spindles were marked visually in 10 normal healthy subjects aged 20-35 years. As a control condition, artifact-free non-spindle epochs 1-3 s before or after the corresponding spindle episodes were marked. Low-resolution electromagnetic tomography demonstrated, independent of the scalp distribution, a distributed spindle source in the prefrontal cortex (Brodmann areas 9 and 10), oscillating with a frequency below 13 Hz, and in the precuneus (Brodmann area 7), oscillating with a frequency above 13 Hz. In extremely rare cases only the prefrontal or the parietal source was active. Brodmann areas 9 and 10 have principal connections to the dorsomedial thalamic nucleus; Brodmann area 7 is connected to the lateroposterior, laterodorsal and rostral intralaminar centrolateral thalamic nuclei. Thus, the localized cortical brain regions are directly connected with adjacent parts of the dorsal thalamus, where sleep spindles are generated.The results demonstrated simultaneously active cortical spindle sources which differed in frequency by approximately 2 Hz and were located in brain regions known to be critically involved in the processing of sensory input, which is in line with the assumed functional role of sleep spindles. (C) 2001 IBRO. Published by Elsevier Science Ltd. All rights reserved.