Synthesis of chiral carbocyclic ribonucleotides.
Synthesis of chiral carbocyclic ribonucleotides.
复制标题
手性碳环核糖核苷酸的合成。
DOI：
10.1080/07328319908044853
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发表时间：
1999
期刊：
影响因子：
--
通讯作者：
Caperelli,CA
中科院分区：
文献类型：
--
作者：
Antle,VD;Caperelli,CA
合成了CMP、UMP、GMP、IMP和核糖- tmp的碳环类似物，它们与天然存在的β- d -核呋喃糖基核糖核苷单磷酸具有相同的绝对构型。该合成路线采用杂环的Mitsunobu偶联，在必要时适当地保护，与差异保护的手性碳环核心。
The carbocyclic analogs of CMP, UMP, GMP, IMP, and ribo-TMP, of the same absolute configuration as the naturally occurring β- D-ribofuranose-based ribonucleoside monophosphates, have been synthesized. The synthetic route employed Mitsunobu coupling of the heterocycles, appropriately protected where necessary, with a differentially protected, chiral carbocyclic core.