Single-Element Ultrasound Transducer for Combined Vessel Localization and Ablation
Single-Element Ultrasound Transducer for Combined Vessel Localization and Ablation
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DOI：
10.1109/tuffc.2011.1869
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发表时间：
2011-04-01
影响因子：
3.6
通讯作者：
Yeh, Chih-Kuang
中科院分区：
文献类型：
--
作者：
Chen, Wen-Shiang;Shen, Che-Chou;Yeh, Chih-Kuang
本报告描述了一种利用单个高强度聚焦超声（HIFU）换能器定位和消融内径为0.5和1.3 mm的动脉的系统。体外和体内试验均证明了该系统的成像和消融功能。成像方式为，从2 mhz HIFU换能器发射脉冲声波（体外3周期，体内10周期，峰值压力2 MPa），由同一换能器采集后向散射超声信号，计算目标区域的多普勒频移。利用多普勒频移的最大信号幅度来确定目标血管的位置。然后切换到治疗模式，通过高强度连续HIFU波（12 MPa）持续60 s成功产生血管闭塞。然后将系统切换回残余血流成像模式，以确定是否需要进行第二次消融治疗。这种新系统可能被用来瞄准和阻塞不需要的血管，比如肿瘤周围的脉管系统，并有助于肿瘤的破坏。
This report describes a system that utilizes a single high-intensity focused ultrasound (HIFU) transducer for both the localization and ablation of arteries with internal diameters of 0.5 and 1.3 mm. In vitro and in vivo tests were performed to demonstrate both the imaging and ablation functionalities of this system. For imaging mode, pulsed acoustic waves (3 cycles for in vitro and 10 cycles for in vivo tests, 2 MPa peak pressure) were emitted from the 2-MHz HIFU transducer, and the backscattered ultrasonic signal was collected by the same transducer to calculate Doppler shifts in the target region. The maximum signal amplitude of the Doppler shift was used to determine the location of the target vessel. The operation mode was then switched to the therapeutic mode and vessel occlusion was successfully produced by high-intensity continuous HIFU waves (12 MPa) for 60 s. The system was then switched back to imaging mode for residual flow to determine the need for a second ablation treatment. The new system might be used to target and occlude unwanted vessels such as vasculature around tumors, and to help with tumor destruction.