Causes of and Molecular Targets for the Treatment of Intervertebral Disc Degeneration: A Review.
Causes of and Molecular Targets for the Treatment of Intervertebral Disc Degeneration: A Review.
复制标题
椎间盘退变的病因及治疗的分子靶点：综述。
作者：
Ohnishi T;Iwasaki N;Sudo H
椎间盘退变(IVDD)是一种病理状态，可导致顽固性背痛或继发性神经功能障碍。这种情况没有根治的方法，目前的治疗重点是间接缓解症状。到目前为止，已经进行了大量的研究，所有IVDD治疗的主要策略是防止由于程序性或调节性细胞死亡而导致的细胞丢失。越来越多的证据表明，除细胞凋亡外，几种类型的细胞死亡，包括坏死性下垂、下垂和铁性下垂，也参与了IVDD。在这项研究中，我们讨论了每种类型细胞死亡的分子途径，并回顾了已确定它们在IVDD中的作用的文献。我们还总结了在RNA水平的靶向治疗的最新进展，包括通过RNA干扰对RNA的调节和对非编码RNA的调节，以防止细胞死亡和随后的IVDD。因此，我们综述了RNA干预的原因和可能的治疗靶点，并讨论了该领域未来的研究方向。
Intervertebral disc degeneration (IVDD) is a pathological condition that can lead to intractable back pain or secondary neurological deficits. There is no fundamental cure for this condition, and current treatments focus on alleviating symptoms indirectly. Numerous studies have been performed to date, and the major strategy for all treatments of IVDD is to prevent cell loss due to programmed or regulated cell death. Accumulating evidence suggests that several types of cell death other than apoptosis, including necroptosis, pyroptosis, and ferroptosis, are also involved in IVDD. In this study, we discuss the molecular pathway of each type of cell death and review the literature that has identified their role in IVDD. We also summarize the recent advances in targeted therapy at the RNA level, including RNA modulations through RNA interference and regulation of non-coding RNAs, for preventing cell death and subsequent IVDD. Therefore, we review the causes and possible therapeutic targets for RNA intervention and discuss the future direction of this research field.
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影响因子：
2.8
作者：
Fields, Aaron J.;Berg-Johansen, Britta;Metz, Lionel N.;Miller, Stephanie;La, Brandan;Liebenberg, Ellen C.;Coughlin, Dezba G.;Graham, James L.;Stanhope, Kimber L.;Havel, Peter J.;Lotz, Jeffrey C.
通讯作者：
Lotz, Jeffrey C.
影响因子：
7.2
作者：
Ding, Fan;Shao, Zeng-Wu;Xiong, Li-Ming
通讯作者：
Xiong, Li-Ming
影响因子：
64.5
作者：
Dixon SJ;Lemberg KM;Lamprecht MR;Skouta R;Zaitsev EM;Gleason CE;Patel DN;Bauer AJ;Cantley AM;Yang WS;Morrison B 3rd;Stockwell BR
通讯作者：
Stockwell BR
影响因子：
7
作者：
Ansari MY;Khan NM;Ahmad I;Haqqi TM
通讯作者：
Haqqi TM
影响因子：
3.1
作者：
Capossela, S.;Schlafli, P.;Stoyanov, J. V.
通讯作者：
Stoyanov, J. V.